Table 4A.
Results of blood, urine and kidney cultures after challenge of dogs with L. interrogans serovar canicola. Dogs were challenged 14 months after a primary course of two doses of vaccine (study 3: duration of immunity).
| Group | Dog no. | Days after challenge |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Blood |
Urine |
Kidney | |||||||||||||
| 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 10 | 0 | 16 | 21 | 35 | 35 | ||
| Vaccinated | 1 | − | +++ | +++ | +++ | − | − | − | − | − | − | − | − | − | − |
| 2 | − | +++ | +++ | +++ | +++ | + | − | − | − | − | ++ | + | − | − | |
| 3 | − | +++ | +++ | +++ | + | − | − | − | − | − | + | ++ | +++ | +++ | |
| 4 | − | +++ | +++ | +++ | + | − | − | − | − | c | − | c | − | − | |
| 5 | − | +++ | ++ | + | − | − | − | − | − | − | − | − | − | − | |
| 6 | − | +++ | ++ | + | − | − | − | − | − | − | − | − | − | − | |
| 7 | − | +++ | +++ | ++ | + | − | − | − | − | c | − | − | − | − | |
| Control (adults) | 8 | − | +++ | +++ | +++ | +++ | − | − | − | − | c | +++ | +++ | − | − |
| 9 | − | +++ | +++ | +++ | +++ | +++ | +++ | ++ | − | − | +++ | +++ | − | − | |
| 10 | − | +++ | +++ | +++ | +++ | ++ | − | ++ | − | c | +++ | + | +++ | +++ | |
| 11 | − | +++ | +++ | +++ | +++ | + | − | + | − | − | ++ | +++ | − | − | |
| 12 | − | +++ | +++ | +++ | +++ | +++ | +++ | ++ | − | − | +++ | c | +++ | − | |
| 13 | − | +++ | +++ | +++ | +++ | − | + | + | − | c | +++ | c | +++ | +++ | |
| 14 | − | +++ | +++ | +++ | +++ | +++ | − | − | − | c | − | c | − | − | |
| 15 | − | +++ | +++ | +++ | +++ | +++ | +++ | +++ | d | − | ++ | d | d | +++ | |
| Control (puppies) | 16 | − | +++ | +++ | +++ | d | d | d | d | d | c | d | d | d | +++ |
| 17 | − | +++ | +++ | +++ | +++ | d | d | d | d | − | d | d | d | c | |
+++, culture positive at dilution 1/1000; ++, culture positive at dilution 1/100; +, culture positive at dilution 1/10; −, culture negative; c = contaminated; d = died or euthanised.