Table 1.
Time | Guinea pigs (no.) | Neutralizing antibodies titera |
||
---|---|---|---|---|
Group A | Group B | Group C | ||
0 dpv | 1 | <0.6 | <0.6 | <0.6 |
2 | <0.6 | <0.6 | <0.6 | |
3 | <0.6 | <0.6 | <0.6 | |
14 dpv (primary) | 1 | 0.9 | 0.9 | <0.6 |
2 | 1.5 | 0.75 | <0.6 | |
3 | 1.2 | 0.9 | <0.6 | |
28 dpv (primary) | 1 | 0.9 | 0.9 | <0.6 |
2 | 1.8 | 1.2 | <0.6 | |
3 | 2.1 | 1.2 | <0.6 | |
14 dpv (boosted) | 1 | 1.5 | 1.5 | <0.6 |
2 | 2.1 | 1.5 | <0.6 | |
3 | 2.1 | 1.5 | <0.6 | |
28 dpv (boosted) | 1 | 1.8 | 1.2 | <0.6 |
2 | 1.5 | 1.5 | <0.6 | |
3 | 2.1 | 1.2 | <0.6 |
Neutralizing antibody determinations were performed with sera sampled at day 0 (prior to vaccination), day 14 and day 28 after the primary and booster vaccinations. Serum samples were obtained from three guinea pigs from each group. dpv: days post vaccination.
Log10 reciprocal antibody titers to neutralize 100 TCID50 of homologous FMDV in 50% of the wells.