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. 2012 Apr 6;159(1):239–244. doi: 10.1016/j.vetmic.2012.03.039

Fig. 2.

Fig. 2

Histopathological (a, b) and immunohistochemical (c, d) findings in pups experimentally infected with strain 450/07. (a) Jejunum of dog 9319: fusion and desquamation of intestinal villi and inflammatory cell infiltration in the lamina propria (H&E, 10×). (b) Lung of dog 9314: diffuse leucocyte infiltration of alveolar walls and epithelial desquamation (H&E, 10×). (c) Ileum of dog 9319: Alphacoronavirus-1 antigen (brown stained) in epithelial cells (IHC with monoclonal antibody, 10×). (d) Popliteal lymph node of dog 9322: Alphacoronavirus-1 antigen (brown stained) in lymphocytic cells (IHC with monoclonal antibody, 20×).