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. 2014 Aug 4;173(3):177–188. doi: 10.1016/j.vetmic.2014.07.020

Table 4.

Synopsis of relevant aa changes in ORF3, ORF7 and spike protein and resulting translation products of FIPV samples. Numbers in brackets indicate number of truncated aa. Onlychanges affecting more than 50% of examined samples are listed. The change in the respective sample is underlined. Numbers refer to positions according to reference strain Black (EU186072). n.s.: not sequenced.

Sample Gene 3a Gene 3b Gene 3c Gene 7a Gene 7b Gene S
FIPV-1F F9L Y170H Deletions (4), M1045L/D1108H/Y, E1267D/Q, T1299A/S, T1311V/S, L1345F
FIPV-1A F9L Y170H Deletions (4), M1045L/D1108H/Y, E1267D/Q,T1311V/S
FIPV-2A Truncation (76) F9L Y170H M1045L/D1108H/Y/D1210N, E1267D/Q, Y1268H, N1275G, T1299A/S, T1308A, T1311V/S, E1315D/N, P1341S/T, L1345F, H1444N, S1454R/N
FIPV-3F F9L Y170H M1045L/D1108H/Y/D1210N, E1267D/Q, Y1268H, N1275G, T1299A/S, T1308A, T1311V/S, E1315D/N, P1341S/T, L1345F, H1444N, S1454R/N
FIPV-3A F9L Y170H M1045L, N1275G, P1341S/T
FIPV-4A Truncation (105) F9L Y170H Only HR2: N1275G, T1308A, E1315D/N
FIPV-5A Truncation (6) No translation product n.s. n.s. n.s.
FIPV-6A Truncation (9) Truncation (9) No translation product n.s. n.s. n.s.
FIPV-7F F9L Y170H E1267D/Q, Y1268H, E1315D/N, S1454R/N
FIPV-8F Truncation (45) n.s. n.s. n.s.
FIPV-8A Truncation (45) n.s. n.s. n.s.
FIPV-9F Truncation (65) n.s. n.s. n.s.
FIPV-9A Truncation (65) n.s. n.s. n.s.
FIPV-10F Truncation (7) n.s. n.s. n.s.
FIPV-10A Truncation (7) Truncation (221) n.s. n.s. n.s.
FIPV-11A Truncation (35) Truncation (132) n.s. n.s. n.s.
FIPV-12F Only HR2
FIPV-12A Truncation (163) Only HR2
FIPV-13F Elongation (8) No translation product n.s. n.s. n.s.
FIPV-14F Truncation (1) F9L M1045L, H1444N
FIPV-15F Truncation (1) M1045L, H1444N
FIPV-15A Truncation (22) Truncation (1) Truncation (110) Y170H H1444N
FIPV-16F Truncation (1) F9L Truncation (171) D1108H/Y/D1210N, E1267D/Q, Y1268H, N1275G, T1299A/S, T1308A, T1311V/S, E1315D/N, P1341S/T, L1345F, H1444N, S1454R/N
FIPV-17F Truncation (1) n.s. n.s. Only 23531: M1045L
FIPV-17A Truncation (1) Truncation (82) Y170H D1108H/Y, D1210N, E1267D/Q, Y1268H, N1275G, T1299A/S, T1308A, T1311V/S, E1315D/N, P1341S/T, L1345F, H1444N, S1454R/N
FIPV-18F No translation product n.s. n.s. n.s.
FIPV-18A No translation product Y170H D1108H/Y/D1210N, E1267D/Q, Y12668H, N1275G, T1299A/S, T1308A, T1311V/S, E1315D/N, P1341S/T, L1345F, H1444N, S1454R/N
FIPV-19F Truncation (1) n.s. n.s. n.s.
FIPV-19A Truncation (1) Truncation (129) n.s. n.s. n.s.