Table 1.
19 loci that dominantly modify the EGFP-3a-induced rough eye phenotype
| Category | Gene | Allele | Modification (Strength)a | Molecular functionb | Human homologueb | Human lung expressionc |
|---|---|---|---|---|---|---|
| Electron transport | Cyt-c-d (dc3) | Cyt-c-dEP2305 | Su(+) | Electron transporter activity; oxidoreductase activity; electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity | Cytochrome c, somatic (CYCS) | Yes |
| Calcium-binding | CalpB | EP(3)875 | Su(++) | Calmodulin binding; calpain activity; calcium ion binding | Calpain 9 (CAN9) | Yes |
| Csp | EP(3)659 | Su(+) | ATPase activity, coupled | DnaJ (Hsp40) homolog, subfamily C, member5 (DNAJC5) | Yes | |
| EP(3)3141 | Su(+) | |||||
| Past1 | Past1EY01852 | E(−) | Calmodulin binding; calcium ion binding | EH-domain containing 1 (EHD1) | Yes | |
| Protein post-translational modification | lwr | lwr02858 | Su(+) | SUMO conjugating enzyme activity; ligase activity; protein binding; ubiquitin conjugating enzyme activity | Ubc9 | Yes |
| Nedd4 | Nedd4EY00500 | Su(+) | Ubiquitin–protein ligase activity | Neural precursor cell expressed, developmentally down-regulated 4-like (NEDD4L) | Yes | |
| Gene transcription | CG12313 | EP(3)3367 | Su(++) | — | Carboxyl-terminal domain, RNA polymerase II, polypeptide A small phosphatase 1 (CTDSP1) | Yes |
| CG6994 | EP(3)691 | Su(++) | Transcription factor activity | — | — | |
| emc | emc[D] | NM | Transcription corepressor activity | Inhibitor of DNA binding | Yes | |
| emc03620 | Su(++) | |||||
| CtBP | Protein C-terminus binding; transcription corepressor activity | C-terminal-binding protein 2 (CTBP2) | Yes | |||
| CtBPEP3352 | Su (+) | |||||
| Nucleic acid binding | CG16940 | CG16940KG02284 | E(−) | Nucleic acid binding; exoribonuclease activity | — | — |
| CG9705 | CG9705KG07795 | E(−) | RNA binding; nucleic acid binding | Calcium regulated heat stable protein 1, 24 kDa (CARHSP1) | Yes | |
| Aats-ile | Aats-ile00827 | Su(+) | RNA binding; isoleucine-tRNA ligase activity | Isoleucine-tRNA synthetase (IARS) | Yes | |
| danr | P{GT1}BG01545 | E(−) | DNA binding | — | — | |
| dan | EP(3)798 | Su(++) | DNA binding | — | — | |
| Unknown functions | CG16971 | CG16971EP3581 | Su(++) | — | — | — |
| l(3)L3809 | l(3)L3809L3809 | Su(++) | — | — | — | |
| CG10252 | PsEY02072 | Su(++) | — | — | — | |
| CG10365 | CG10365KG00107 | E(−) | — | Hypothetical protein MGC4504 | Yes |
a
Strengths of modification: NM, no modification; Su(++), strong suppressor; Su(+), weak suppressor; E(−), weak enhancer.
b
Description of “Molecular Function” was adapted from FlyBase reports (http://www.flybase.net/).
c
Based on information obtained from the NCBI UniGene database.