TABLE 1.
Bactericidal activities of TB drugs against M. tuberculosis in ex vivo caseum and in vitro under replicating and nonreplicating conditionsa
| Antibiotic | Caseum MBC90 (μM) | MBC90 (μM)b | WCC90 (μM)b | LCC90 (μM)b |
|---|---|---|---|---|
| Isoniazid | >128 | 0.31–0.63 | >100 | >100 |
| Pyrazinamide | 512 | >80 | >100 | >100 |
| Rifampin | 8 | 0.078 | 1 | 10 |
| Rifapentine | 2 | 0.078 | 0.5 | 10 |
| Rifabutin | 2 | 0.039 | 0.5 | 10 |
| Rifalazil | 2 | 0.036c | ||
| Moxifloxacin | 2 | 0.31–0.63 | 10 | >100 |
| Levofloxacin | 8 | 1.25–2.5 | 50 | >100 |
| Gatifloxacin | 2 | 0.63 | 50 | >100 |
| Linezolid | 128 | 10 | >100 | >100 |
| Radezolid | 2 | |||
| Pretomanid | 32 | 0.63 | 20 | |
| Kanamycin | >128 | 5.0 | 20 | >100 |
| Clofazimine | >128 | 40 | 50 | >100 |
| Bedaquiline | 32 | 10 | >20 | >20 |
a
Adapted from the work of Sarathy et al. (13). MBC90, minimum concentration required to kill 90% of the bacterial population; WCC, Wayne (hypoxic culture) bactericidal concentration; LCC, Loebel (nutrient starved culture) bactericidal concentration.
b
Most MBC and all WCC and LCC data were obtained from Lakshminarayana et al. (119).
c
MBC90 data for rifalazil were obtained from Mor et al. (153).