TABLE 3.

Detection of hypoxic granulomas in various species using different techniques^a

Species	Caseous necrosis	Measurement technique	pO2	Reference
BALB/c mouse	Absent	Immunodetection of PIMO	Not hypoxic	8
		[64Cu]ATSM PET imaging	Not hypoxic	8
C57BL/6 mouse	Absent	Immunodetection of EF5	Not hypoxic	109
		Immunodetection of PIMO	Not hypoxic	115
		Catheter microelectrode	Not hypoxic	115
C3HeB/FeJ mouse	Present	Immunodetection of PIMO	<10 mm Hg	8
		Immunodetection of PIMO	<10 mm Hg	7
		[64Cu]ATSM PET imaging	<3.8 mm Hg	8
Guinea pig	Present	Immunodetection of PIMO	<10 mm Hg	111
		Immunodetection of PIMO	<10 mm Hg	3
Rabbit	Present	Immunodetection of PIMO	<10 mm Hg	111
		Fiber optic oxygen sensor	1.6 mm Hg	111
Cynomolgus macaque	Present	Immunodetection of PIMO	<10 mm Hg	111
		Immunodetection of PIMO	<10 mm Hg	122
Human	Present	[18F]FMISO PET-CT imaging	<10 mm Hg	113

^a[⁶⁴Cu] ATSM PET, ⁶⁴Cu-diacetyl-bis (N⁴-methylthiosemicarbazone) positron emission tomography; EF5, 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[18F]pentafluoropropyl)-acetamide; PIMO, pimonidazole hydrochloride; [¹⁸F]FMISO, [¹⁸F]fluoromisonidazole.