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. 2016 Apr 11;2016(4):CD009002. doi: 10.1002/14651858.CD009002.pub3
Source Search strategy Hits retrieved
1. ALOIS (www.medicine.ox.ac.uk/alois) but searched via the offline CRS
(last searched 10 December 2015)		 [Omega OR "fatty acid*" OR PUFA OR EPA OR DHA OR ALA "alpha linolenic acid*" OR "docosahexaenoic acid*" OR "docosapentanoic acid*" OR "eicosapentaenoic acid*"] AND Study Aim: Treatment Dementia AND Study design: RCT OR CCT March 2015: 70
December 2015: 2
2. MEDLINE In‐process and other non‐indexed citations and MEDLINE 1946‐present (OvidSP) (last searched 10 December 2015) 1. dement*.mp.
2. alzheimer*.mp.
3. ((cognit* adj3 impair*) or mci).mp.
4. (memory adj3 (impair* or insufficien* or episode or complain*)).mp.
5. ("functional impair*" or MFI).ab.
6. cognit* declin*.mp.
7. ("cognitive impairment no dementia" or CIND).mp.
8. exp Dementia, Vascular/
9. "vascular dementia".mp.
10. exp Lewy Bodies/
11. ("lewy* bod*" or DLB).mp.
12. (AAMI or AACD).mp.
13. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12
14. exp "fatty acids"/
15. "fatty acids, omega 3"/
16. ("fatty acid*" or fats or omega‐3).mp.
17. (PUFA* or polyunsaturated).mp.
18. (EPA or "eicosapentaenoic acid*").mp.
19. (ALA or "alpha linolenic acid*").mp.
20. (DHA or "docosahexaenoic acid*").mp.
21. (DPA or "docosapentanoic acid*").mp.
22. n‐3‐fatty‐acid*.mp.
23. ("flaxseed oil" or "linseed oil" or "fish oil*" or "salmon oil" or "cod liver oil" or "mackerel oil" or "tuna* oil" or "tuna fish oil" or "blackcurrant oil" or "canola oil" or "rapeseed oil" or "mustard oil*" or "walnut oil" or "wheat germ oil" or "dental oil*").mp.
24. 21 or 17 or 20 or 15 or 14 or 22 or 18 or 23 or 16 or 19
25. 24 and 13
26. randomized controlled trial.pt.
27. Controlled clinical trial.pt.
28. randomi?ed.ti.
29. randomi?ed.ab.
30. placebo.ab.
31. drug therapy.fs.
32. randomly.ab.
33. trial.ab.
34. groups.ab.
35. "meta analys*".ab.
36. 35 or 27 or 33 or 32 or 28 or 26 or 34 or 30 or 29 or 31
37. (animals not (humans and animals)).sh.
38. 36 not 37
39. 38 and 25		 March 2015: 863
December 2015: 76
3. EMBASE
1974‐2015 December 09 (OvidSP)
(last searched 10 December 2015)		 1. exp dementia/
2. Lewy body/
3. delirium/
4. Wernicke encephalopathy/
5. cognitive defect/
6. dement*.mp.
7. alzheimer*.mp.
8. (lewy* adj2 bod*).mp.
9. deliri*.mp.
10. (chronic adj2 cerebrovascular).mp.
11. ("organic brain disease" or "organic brain syndrome").mp.
12. "supranuclear palsy".mp.
13. ("normal pressure hydrocephalus" and "shunt*").mp.
14. "benign senescent forgetfulness".mp.
15. (cerebr* adj2 deteriorat*).mp.
16. (cerebral* adj2 insufficient*).mp.
17. (pick* adj2 disease).mp.
18. CADASIL.mp.
19. "cognit* impair*".mp.
20. exp mild cognitive impairment/
21. MCI.ti,ab.
22. ACMI.ti,ab.
23. ARCD.ti,ab.
24. SMC.ti,ab.
25. CIND.ti,ab.
26. BSF.ti,ab.
27. AAMI.ti,ab.
28. MD.ti,ab.
29. LCD.ti,ab.
30. QD.ti,ab.
31. AACD.ti,ab.
32. MNCD.ti,ab.
33. MCD.ti,ab.
34. ("N‐MCI" or "A‐MCI" or "M‐MCI").ti,ab.
35. ((cognit* or memory or cerebr* or mental*) adj3 (declin* or impair* or los* or deteriorat* or degenerat* or complain* or disturb* or disorder*)).ti,ab.
36. "preclinical AD".mp.
37. "pre‐clinical AD".mp.
38. ("preclinical alzheimer*" or "pre‐clinical alzheimer*").mp.
39. (aMCI or MCIa).ti,ab.
40. ("CDR 0.5" or "clinical dementia rating scale 0.5").ti,ab.
41. ("GDS 3" or "stage 3 GDS").ti,ab.
42. ("global deterioration scale" and "stage 3").mp.
43. "Benign senescent forgetfulness".ti,ab.
44. "mild neurocognit* disorder*".ti,ab.
45. (prodrom* adj2 dement*).ti,ab.
46. "age‐related symptom*".mp.
47. (episodic adj2 memory).mp.
48. ("pre‐clinical dementia" or "preclinical dementia").mp.
49. or/1‐48
50. ("omega 3" or "fatty acid*" or "n‐3‐fatty‐acid*").ti,ab.
51. (PUFA* or polyunsaturated).ti,ab.
52. (EPA or "eicosapentaenoic acid*").ti,ab.
53. (ALA or "alpha linolenic acid*").ti,ab.
54. (DHA or "docosahexaenoic acid*").ti,ab.
55. (DPA or "docosapentanoic acid*").ti,ab.
56. ("flaxseed oil" or "linseed oil" or "fish oil*" or "salmon oil" or "cod liver oil" or "mackerel oil" or "tuna* oil" or "tuna fish oil" or "blackcurrant oil" or "canola oil" or "rapeseed oil" or "mustard oil*" or "walnut oil" or "wheat germ oil" or "dental oil*").ti,ab.
57. exp *fatty acid/
58. or/50‐57
59. 49 and 58
60. randomized controlled trial/
61. controlled clinical trial/
62. randomly.ab.
63. placebo.ab.
64. groups.ab.
65. randomi?ed.ti,ab.
66. trial.ab.
67. "double‐blind*".ti,ab.
68. or/60‐67
69. 59 and 68		 March 2015: 889
December 2015: 128
4. PsycINFO
1806‐December week 2 2015 (OvidSP)
(last searched 10 December 2015)		 1. exp Dementia/
2. exp Delirium/
3. exp Huntingtons Disease/
4. exp Kluver Bucy Syndrome/
5. exp Wernickes Syndrome/
6. exp Cognitive Impairment/
7. dement*.mp.
8. alzheimer*.mp.
9. (lewy* adj2 bod*).mp.
10. deliri*.mp.
11. (chronic adj2 cerebrovascular).mp.
12. ("organic brain disease" or "organic brain syndrome").mp.
13. "supranuclear palsy".mp.
14. ("normal pressure hydrocephalus" and "shunt*").mp.
15. "benign senescent forgetfulness".mp.
16. (cerebr* adj2 deteriorat*).mp.
17. (cerebral* adj2 insufficient*).mp.
18. (pick* adj2 disease).mp.
19. (creutzfeldt or jcd or cjd).mp.
20. huntington*.mp.
21. binswanger*.mp.
22. korsako*.mp.
23. ("parkinson* disease dementia" or PDD or "parkinson* dementia").mp.
24. "cognit* impair*".mp.
25. MCI.ti,ab.
26. ACMI.ti,ab.
27. ARCD.ti,ab.
28. SMC.ti,ab.
29. CIND.ti,ab.
30. BSF.ti,ab.
31. AAMI.ti,ab.
32. MD.ti,ab.
33. LCD.ti,ab.
34. QD.ti,ab.
35. AACD.ti,ab.
36. MNCD.ti,ab.
37. MCD.ti,ab.
38. ("N‐MCI" or "A‐MCI" or "M‐MCI").ti,ab.
39. ((cognit* or memory or cerebr* or mental*) adj3 (declin* or impair* or los* or deteriorat* or degenerat* or complain* or disturb* or disorder*)).ti,ab.
40. "preclinical AD".mp.
41. "pre‐clinical AD".mp.
42. ("preclinical alzheimer*" or "pre‐clinical alzheimer*").mp.
43. (aMCI or MCIa).ti,ab.
44. ("CDR 0.5" or "clinical dementia rating scale 0.5").ti,ab.
45. ("GDS 3" or "stage 3 GDS").ti,ab.
46. ("global deterioration scale" and "stage 3").mp.
47. "Benign senescent forgetfulness".ti,ab.
48. "mild neurocognit* disorder*".ti,ab.
49. (prodrom* adj2 dement*).ti,ab.
50. "age‐related symptom*".mp.
51. (episodic adj2 memory).mp.
52. ("pre‐clinical dementia" or "preclinical dementia").mp.
53. or/1‐52
54. exp Fatty Acids/
55. ("fatty acid*" or fats or omega‐3).mp.
56. ("flaxseed oil" or "linseed oil" or "fish oil*" or "salmon oil" or "cod liver oil" or "mackerel oil" or "tuna* oil" or "tuna fish oil" or "blackcurrant oil" or "canola oil" or "rapeseed oil" or "mustard oil*" or "walnut oil" or "wheat germ oil" or "dental oil*").mp.
57. n‐3‐fatty‐acid*.mp.
58. (PUFA* or polyunsaturated).mp.
59. (EPA or "eicosapentaenoic acid*").mp.
60. (ALA or "alpha linolenic acid*").mp.
61. (DHA or "docosahexaenoic acid*").mp.
62. (DPA or "docosapentanoic acid*").mp.
63. or/54‐62
64. 53 and 63
65. random*.ti,ab.
66. placebo.ti,ab.
67. trial.mp.
68. ("double‐blind*" or "single‐blind*").ti,ab.
69. groups.ab.
70. crossover.ti,ab.
71. "cross‐over".ti,ab.
72. or/65‐71
73. 64 and 72		 March 2015: 175
December 2015: 19
5. CINAHL (EBSCOhost)
(last searched 10 December 2015)		 S1 (MH "Dementia+")
S2 (MH "Delirium") or (MH "Delirium, Dementia, Amnestic, Cognitive Disorders")
S3 (MH "Wernicke's Encephalopathy")
S4 TX dement*
S5 TX alzheimer*
S6 TX lewy* N2 bod*
S7 TX deliri*
S8 TX chronic N2 cerebrovascular
S9 TX "organic brain disease" or "organic brain syndrome"
S10 TX "normal pressure hydrocephalus" and "shunt*"
S11 TX "benign senescent forgetfulness"
S12 TX cerebr* N2 deteriorat*
S13 TX cerebral* N2 insufficient*
S14 TX pick* N2 disease
S15 TX creutzfeldt or jcd or cjd
S16 TX huntington*
S17 TX binswanger*
S18 TX korsako*
S19 TX MCI OR CIND OR AAMI OR AACD
S20 TX "cognit* impair*"
S21 (MH "Cognition Disorders")
S22 TX "pre‐clinical alzheimer*" OR "pre‐clinical AD"
S23 TX "N‐MCI" OR "A‐MCI" OR "M‐MCI"
S24 TX aMCI OR nMCI OR mMCI
S25 S1 or S2 or S3 or S4 or S5 or S6 or S7 or S8 or S9 or S10 or S11 or S12 or S13 or S14 or S15 or S16 or S17 or S18 or S19 or S20 or S21 or S22 or S23 or S24
S26 (MH "Fatty Acids, Omega 3") OR (MM "alpha‐Linolenic Acid") OR (MM "Docosahexaenoic Acids") OR (MM "Eicosapentaenoic Acid")
S27 (MH "Linseed Oil") OR (MH "Margarine") OR (MH "Olive Oil") OR (MH "Peanut Oil") OR (MH "Rapeseed Oil") OR (MH "Safflower Oil") OR (MH "Sesame Oil") OR (MH "Soybean Oil")
S28 TX "fatty acid*" OR fats OR "omega‐3"
S29 TX "flaxseed oil" OR "linseed oil" OR "fish oil*" OR "salmon oil" OR "cod liver oil" OR "mackerel oil" OR "tuna* oil" OR "tuna fish oil" OR "blackcurrant oil" OR "canola oil" OR "rapeseed oil" OR "mustard oil*" OR "walnut oil" OR "wheat germ oil" OR "dental oil*"
S30 TX n‐3‐fatty‐acid*
S31 TX PUFA* OR polyunsaturated
S32 TX EPA OR "eicosapentaenoic acid*"
S33 TX ALA OR "alpha linolenic acid*"
S34 TX DHA OR "docosahexaenoic acid*"
S35 TX DPA OR "docosapentanoic acid*"
S36 S26 or S27 or S28 or S29 or S30 or S31 or S32 or S33 or S34 or S35
S37 S25 and S36
S38 AB random*
S39 TI random*
S40 TI placebo*
S41 AB placebo*
S42 AB trial
S43 (MH "Clinical Trials") OR (MH "Randomized Controlled Trials")
S44 AB groups
S45 AB "double‐blind*"
S46 S38 or S39 or S40 or S41 or S42 or S43 or S44 or S45
S47 S37 and S46		 March 2015: 68
December 2015: 14
6. ISI Web of Knowledge ‐ all databases (includes: Web of Science (1945‐present); BIOSIS Previews (1926‐present); MEDLINE (1950‐present); Journal Citation Reports)
(last searched 10 December 2015)		 (dement* OR alzheimer* OR "lewy bod*" OR DLB OR "vascular cognitive impairment*" OR FTD OF FTLD OR "cerebrovascular insufficienc*") AND TOPIC: (omega OR "fatty acid*" OR ALA OR "alpha linolenic acid*" OR PUFA* or polyunsaturated OR EPA or "eicosapentaenoic acid*" OR "flaxseed oil" OR "linseed oil" OR "fish oil*" OR "salmon oil" OR "cod liver oil" OR "mackerel oil" OR "tuna* oil" OR "tuna fish oil" OR "blackcurrant oil" OR "canola oil" OR "rapeseed oil" OR "mustard oil*" OR "walnut oil" OR "wheat germ oil" OR "dental oil*") AND TOPIC: (randomly OR randomised OR randomized OR placebo OR "double‐blind*" OR trial OR RCT OR CCT)
Timespan: All years
Search language=Auto		 March 2015: 513
December 2015: 116
7. LILACS (BIREME)
(last searched 10 December 2015)		 Omega‐3 OR PUFA OR polyunsaturated OR EPA OR DHA OR "poli‐insaturados" OR "ômega‐3" [Words] and dementia OR demencia OR alzheimer OR alzheimers [Words] March 2015: 7
December 2015: 0
8. The Cochrane Central Register of Controlled Trials (CENTRAL) (2015 Issue 11 of 12)
(last searched 10 December 2015)		 #1 MeSH descriptor: [Dementia] explode all trees
#2 MeSH descriptor: [Delirium] this term only
#3 MeSH descriptor: [Wernicke Encephalopathy] this term only
#4 MeSH descriptor: [Delirium, Dementia, Amnestic, Cognitive Disorders] this term only
#5 dement*
#6 alzheimer*
#7 "lewy* bod*"
#8 deliri*
#9 "chronic cerebrovascular"
#10 "organic brain disease" or "organic brain syndrome"
#11 "normal pressure hydrocephalus" and "shunt*"
#12 "benign senescent forgetfulness"
#13 "cerebr* deteriorat*"
#14 "cerebral* insufficient*"
#15 "pick* disease"
#16 creutzfeldt or jcd or cjd
#17 huntington*
#18 binswanger*
#19 korsako*
#20 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19
#21 MCI or "cognit* impair*" or AAMI or "memory impair*" or "cognit* declin*" or AACD
#22 #20 or #21 in Trials
#23 "omega 3" or "fatty acid*" or PUFA or EPA or ALA or DHA or DPA
#24 "eicosapentaenoic acid*" or "alpha linolenic acid*" or "docosahexaenoic acid*" or "docosapentanoic acid*"
#25 "n‐3‐fatty‐acid*" or polyunsaturated or "flaxseed oil" or "linseed oil" or "fish oil*" or "salmon oil" or "cod liver oil" or "mackerel oil" or "tuna* oil" or "tuna fish oil" or "blackcurrant oil" or "canola oil" or "rapeseed oil" or "mustard oil*" or "walnut oil" or "wheat germ oil" or "dental oil*"
#26 MeSH descriptor: [Fatty Acids] this term only
#27 #23 or #24 or #25 or #26 in Trials
#28 #22 and #27 in Trials		 March 2015: 159
December 2015: 18
9. Clinicaltrials.gov (www.clinicaltrials.gov)
(last searched 10 December 2015)		 (dementia OR alzheimer OR alzheimers OR alzheimer's OR lewy) AND (omega OR PUFA OR EPA OR DHA OR "fatty acid" OR "fatty acids" OR polyunsaturated) March 2015: 14
December 2015: 5
10. ICTRP Search Portal (apps.who.int/trialsearch) [includes: Australian New Zealand Clinical Trials Registry; ClinicalTrilas.gov; ISRCTN; Chinese Clinical Trial Registry; Clinical Trials Registry ‐ India; Clinical Research Information Service ‐ Republic of Korea; German Clinical Trials Register; Iranian Registry of Clinical Trials; Japan Primary Registries Network; Pan African Clinical Trial Registry; Sri Lanka Clinical Trials Registry; The Netherlands National Trial Register]
(last searched 10 December 2015)		 (dementia OR alzheimer OR alzheimers OR alzheimer's OR lewy) AND (omega OR PUFA OR EPA OR DHA OR "fatty acid" OR "fatty acids" OR polyunsaturated) March 2015: 3
December 2015: 0
TOTAL before de‐duplication March 2015: 2761
December 2015: 303
TOTAL after software de‐duplication March 2015: 1992
December 2015: 239