Figure 1. CYP2C8 gene and known single nucleotide polymorphisms [101].

Only the single nucleotide polymorphisms present in the coding region of the gene are represented.

ºAlleles coding for documented or predicted reduced enzyme activity;

*2: Two-fold higher K_M for paclitaxel transformation [17];

*3: 15% of *1-associated turnover number [17];

*5: Expected to be an inactive gene [18];

*7: No in vitro detectable activity [21];

*8: In vitro enzyme activity 10% of the wild-type [21];

P404A: Reduced protein expression leading to decreased V_max/K_M [32].