Table 1. Published prevalences of the main CYP2C8 alleles in malaria-endemic regions.

Allele‡	Malaria-affected regions		Comparators*
	Zanzibar (n = 16)	Ghana (n = 200)	Malaysia (n = 57)	Papua New Guinea (n = 305)	SE Asia (n = 20)		African–Americans	Western Europeans	Japanese
CYP2C8*2	0.139	0.168	0.035	0.000	0.000		0.180–0.150	0.004–0.016	0.000
CYP2C8*3	0.021	0.000	0.053	0.000	0.050		0.020–0.080	0.069–0.198	0.000–0.007
CYP2C8*4	0.006	0.000	0.000	0.000	0.000		0.000	0.045–0.075	0.000
LM	0.036	0.015	<0.005	0.000	0.000		0–0.019	0–0.067	0.000
Ref.	[72]	[73]	[74]	[50]	[75]		[17,76,77]	[78]	[19,21,79]

^*Data concerning average values derived from studies in African–American, Japanese and Western Europeans are given as comparators.

^‡Other rare alleles were essentially only found in Japanese: *5 = 0.003 [76] and 0.009 [19]; *6 = 0.003; *7 = 0.003; *8 = 0.003; *9 = 0.003; *10 = 0.003 [21].

CYP: Cytochrome P450; LM: Low-metabolizer, inferred from the frequency of subjects homozygous for the mutant alleles.