Fig 8. viP₁₁A6L causes weight loss and mortality similar to WR in the presence of DOX.

Groups of female CB6F₁/J mice (n = 10) were inoculated intranasally with ~2 × 10⁶ PFU viP₁₁A6L or WR in the absence or presence of DOX. Weight and mortality were assessed daily. Animals were euthanized if weight loss was ≥ 25%. Mean group weights as a percentage of group weight on Day 0 (A), or percent survival (B) are shown. Asterisks indicate statistical significance (p < 0.01) by one-way ANOVA followed by Sidak’s multiple comparisons test (A), or by log-rank (Mantel-Cox) test between indicated groups adjusted for multiple comparisons using the Bonferroni post-hoc test (B). Error bars indicate standard deviation.