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. 2020 Apr 2;15(4):e0230231. doi: 10.1371/journal.pone.0230231

Fig 6. Effect of 24 h treatment with acetate (ACET), butyrate (BUT), or propionate (PROP) at 10 mM.

Fig 6

Gene expression of differentiation markers: stem cells (Lgr5), enterocyte alkaline phosphatase (Alpi), goblet cell mucin 2 (Muc2), enteroendocrine cell chromogranin A (Chga), Paneth cell lysozyme (Lyz), tight junction markers claudin-3 (Cldn3), occludin (Ocln), zonula-occludens 1 (Tjp1), Tuft cell marker Dclk1, anti-microbial peptide expression Reg3β, Reg3γ, and beta-defensin 1 (Defb1) were analyzed in human 2D duodenal enteroids. Treatments are compared to controls (CON) which are set to 1.0 and superscripts (a,b,c,d) indicate statistical significance between treatments at P < 0.05, n = 4.