(A) Fluctuation of the per hectare (USD) and total (USD millions) economic losses from 1996 to 2016 due to 23 diseases across 28 states (AL, AR, DE, FL, GA, IA, IL, IN, KS, KY, LA, MD, MI, MN, MO, MS, NC, ND, NE, OH, OK, PA, SC, SD, TN, TX, VA, and WI). (B) The estimated total economic loss (USD per hectare) associated with 23 diseases across 21 years (1996 to 2016) and 28 states in descending order: SCN = soybean cyst nematodes, CHAR = charcoal rot, SEED = seedling diseases, PRR = Phytophthora root and stem rot, RKNOT = root-knot and other nematodes, SDS = sudden death syndrome, SSR = Sclerotinia stem rot (white mold), SEP = Septoria brown spot, FLS = Frogeye leaf spot, DIAPHOM = Diaporthe-Phomopsis, CLBPSS = Cercospora leaf blight (purple seed stain), PODSTEM = pod and stem blight, ANT = Anthracnose, BSR = Brown stem rot, FW = Fusarium wilt, VIRUS = virus diseases, SC = stem canker, OTHER = other diseases, DM = downy mildew, RAB = Rhizoctonia aerial blight, SR = soybean rust, BAC = bacterial blight, SB = southern blight. (C) Fluctuation of the total economic losses (across 28 states) associated with soybean cyst nematode, charcoal rot, and all the other diseases together during 1996 to 2016 period.