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EGL-43L plays two distinct functions during AC invasion. Left side: EGL-43L represses LIN-12 Notch expression in the differentiated AC to prevent proliferation. In addition, EGL-43 and NHR-67 positively regulate each other, and NHR-67 controls CKI-1 expression to maintain the G1 arrest of the AC. Right side: EGL-43L activates in a positive feedback loop together with FOS-1 the expression of pro-invasive genes in the AC.
