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. 2020 Mar 23;16(3):e1008243. doi: 10.1371/journal.ppat.1008243

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© 2020 Zawawi et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A) PRISMA flow diagram of the systematic review screening process for restricted MHC-II T-cell bioinformatics prediction tools. A list of search terms was used in Google website and other website sources to screen for MHC class I and II in silico prediction tools. Aspects relating to the number of citations (>200), number of publications, online availability, last update and community were used as inclusion/exclusion criteria to select the top MHC-II in silico prediction tools. n = number of key words, websites sources and in silico prediction tools. (B) The flow diagram of reverse vaccinology approach to identify potential vaccine candidates (MHC-II T-cell epitopes) from the T. muris genome. The number on the arrow represents the number of proteins or epitopes selected for the next step. (C) List of 4 Trichuris MHC-II T-cell epitopes which have potential as vaccine candidates.