Table 2: Representative β-cell-derived peptides identified in the MHC-II peptidomes.
Shown are representative peptide sequences from each peptide families depicted in Table 1. The peptides are identified in the MHCII peptidome of both islets and peripheral lymphoid tissues (Islet + Periphery; blue) or only in the islets (Islet only; yellow).
| Sites | Peptide | Sequence |
|---|---|---|
| Islet + Periphery | InsB:9–23 | SHLVEALYLVCGERG |
| Ins1C:33–61 | EVEDPQVEQLELGGSPGDLQTLALEVARQ | |
| Ins1C:37–56 | PQVEQLELGGSPGDLQTLAL | |
| Ins1C:37–61 | PQVEQLELGGSPGDLQTLALEVARQ | |
| Ins1C:51–61 | LQTLALEVARQ | |
| Ins1C:53–61E | TLALEVARE | |
| Ins2C:33–63 | EVEDPQVAQLELGGGPGAGDLQTLALEVAQQ | |
| IAPP:78–90 | NAARDPNRESLDF | |
| InsC-IAPP | LQTLALNAARD | |
| ZnT8:313–326 | ILSVHVATAASQDS | |
| DBP:389–405 | SPLLKRQLTSFIEKGQE | |
| HSP:167–181 | EIAQVATISANGDKD | |
| Islet only | ChgA:358–371 | WSRMDQLAKELTAEKR |
| Scg1:64–86 | SGKEVKGEEKGENQNSKFEVRLL | |
| Scg1:335–355 | SHHLAHYRASEEEPEYGEESRSY | |
| Scg1:438–454 | LLDEGHYPVRESPIDTA | |
| Scg1:516–535 | LGALFNPYFDPLQWKNSDFE | |
| Scg2:28–41 | ASFQRNQLLQKEPD | |
| Scg2:287–297 | SGQLGLPDEEN | |
| Scg2:569–578 | IPVGSLKNED | |
| Scg5:27–57 | YSPRTPDRVSETDIQRLLHGVMEQLGIARPR |