Table 3. Putative MHCII-bound HIP sequences obtained from the initial database search.
One HIP sequence was verified by matching to a synthetic standard (blue). For four peptides the spectra of the synthetic standards did not match the biological samples (yellow), a probable correct assignment is given.
| Source | Putative HIP sequence | Probable correct assignment | Match to synthetic standard |
|---|---|---|---|
| Islets, pLN | LQTLAL-NAARD | NA | Yes |
| Islets, pLN | PQVEQLELGGSPGDLQ-APV | PQVEQLELGGSPGDLQT(-H2O)LA | no |
| Islets | PQVEQLEL-WSRMDQLAK | PQVEQLELGGSPGD(+Na)LQTLAL | no |
| pLN | PQVEQLELGGSP-APVDN | PQVEQLELGGSPGDLQt(-H2O) | no |
| pLN | PQVEQLEL-GNP | PQVEQLELGGGP | no |