Table 3b.
Percentage change in infant serum concentrations of DHEAS and 17-hydroxyprogesterone (17-OHP) during mini puberty for a two-fold increase in maternal serum PFAA concentrations
| Compound (ng/mL) | DHEAS |
17-OHP |
||||
|---|---|---|---|---|---|---|
| All (N=373) | Girls (N=165) | Boys (N=208) | All (N=373) | Girls (N=165) | Boys (N=208) | |
| % Change (95 % CI) | % Change (95 % CI) | % Change (95 % CI) | % Change (95 % CI) | % Change (95 % CI) | % Change (95 % CI) | |
| PFHxS (ng/mL) | ||||||
| Crude a | 7.0 (−3.5; 18.6) | 4.9 (−10.8; 23.2) | 8.5 (−5.2; 24.3) | 1.7 (−5.0, 8.9) | −2.2 (−11.9, 8.7) | 4.4 (−4.4, 14.0) |
| Adjusted b | 5.2 (−5.5; 17.0) | 2.9 (−12.7, 21.1) | 6.8 (−6.9, 22.5) | 1.1 (−5.7, 8.4) | −2.8 (−12.6, 8.2) | 3.9 (−5.0, 13.6) |
| PFOS (ng/mL) | ||||||
| Crude a | 0.4 (−13.6; 16.8) | −8.3 (−26.7; 14.7) | 8.1 (−11.8; 32.4) | 2.6 (−7.1, 13.4) | 2.7 (−11.2, 18.8) | 3.0 (−9.7; 17.6) |
| Adjusted b | −2.1 (−16.0; 14.1) | −10.4 (−28.4, 12.2) | 5.3 (−14.2, 29.3) | 2.2 (−7.5, 12.9) | 2.1 (−11.9, 18.2) | 2.3 (−10.5, 17.0) |
| PFOA (ng/mL) | ||||||
| Crude a | −0.2 (−11.0, 11.8) | 5.9 (−10.0, 24.6) | −5.5 (−19.3, 10.7) | 3.5 (−4.0, 11.5) | 3.9 (−6.5, 15.5) | 2.4 (−7.6, 13.5) |
| Adjusted b | −5.1 (−16.3, 7.7) | 0.4 (−15.5, 19.3) | −9.9 (−23.7, 6.4) | 2.3 (−5.8, 11.0) | 3.0 (−7.9, 15.2) | 1.6 (−8.8, 13.2) |
| PFNA (ng/mL) | ||||||
| Crude a | −2.6 (−16.0, 13.0) | −1.5 (−21.3, 23.4) | −3.4 (−20.8, 17.7) | 2.6 (−7.0, 13.1) | 3.9 (−10.2, 20.2) | 1.6 (−10.6, 15.5) |
| Adjusted b | −5.5 (−18.8, 10.0) | −5.4 (−24.8, 18.9) | −5.6 (−22.6, 15.2) | 1.8 (−7.8, 12.4) | 2.8 (−11.4, 19.4) | 1.0 (−11.2, 15.0) |
| PFDA (ng/mL) | ||||||
| Crude a | −11.1 (−24.1, 4.1) | −16.0 (−35.0, 8.8) | −7.7 (−24.1, 12.1) | −1.6 (−11.4, 9.2) | −5.5 (−20.1, 11.8) | 0.7 (−11.5, 14.7) |
| Adjusted b | −12.3 (−25.1, 2.7) | −18.9 (−37.5, 5.2) | −8.3 (−24.8, 11.9) | −2.1 (−11.7, 8.6) | −6.5 (−21.2, 10.8) | 0.6 (−11.6, 14.6) |
Note: CI, Confidence interval; DHEA, dehydroepiandrosterone; DHEAS, Dehydroepiandrosterone-sulfate; PFDA, Perfluorodecanoic acid; PFHxS, Perfluorohexane sulfonic acid; PFOA, Perfluorooctanoic acid; PFOS, Perfluorooctane sulfonic acid; PFNA, Perfluorononanoic acid
a
Adjusted for age of the child at examination time.
b
Adjusted for age of the child at examination time, maternal parity, and sex of the child (not in sex-specific analyses).
*
p-value<0.05