Table 3 –
Odds ratios (ORs)a and 95% credible intervals (CIs) of oral and pharyngeal cancer and laryngeal cancer in current smokers, for the joint effect of intensity (cigarettes/day) and duration (years) of cigarette smoking estimated through step-function as compared with results from bivariate spline models. INHANCE consortium
| Intensity (cigarettes/day) | ||||||
|---|---|---|---|---|---|---|
| Cancer type | 1–15 | 16–25 | 26–40 | |||
| Ca:Co | OR (95%CI) [Min-Max]b | Ca:Co | OR (95%CI) [Min-Max]b | Ca:Co | OR (95%CI) [Min-Max]b | |
| Oral cavity and pharynx | ||||||
| Duration (years) | ||||||
| 1–25 | 322:1,046 | 1.5 (1.4–1.7) | 371:663 | 2.7 (2.4–2.9) | 191:270 | 3.3 (2.8–3.9) |
| [0.9–3.1] | [0.9–4.2] | [0.8–5.9] | ||||
| 26–35 | 583:911 | 2.9 (2.7–3.1) | 1,138:954 | 5.1 (4.9–5.4) | 849:466 | 7.2 (6.7–7.8) |
| [1.4–4.8] | [3.5–6.9] | [4.6–11.0] | ||||
| 36–51 | 912:1,175 | 3.7 (3.5–3.9) | 1,838:1,409 | 6.0 (5.8–6.2) | 1,413:694 | 8.4 (8.0–8.9) |
| [1.6–5.8] | [5.2–7.1] | [7.1–10.6] | ||||
| Larynx | ||||||
| Duration (years) | ||||||
| 1–25 | 75:908 | 3.8 (3.3–4.4) | 112:576 | 9.4 (8.3–10.5) | 70:247 | 14.8 (12.2–17.8) |
| [1.1–8.8] | [2.3–20.1] | [2.8–23.1] | ||||
| 26–35 | 183:812 | 7.3 (6.9–7.9) | 423:845 | 17.2 (16.8–17.6) | 319:415 | 28.5 (27–30.2) |
| [2.9–12.6] | [10.1–29.6] | [22.4–37.7] | ||||
| 36–51 | 394:1,064 | 8.9 (8.8–9.1) | 966:1,274 | 19.5 (19.3–19.8) | 718:616 | 33.9 (33.5–34.3) |
| [3.9–15.3] | [13.9–31.0] | [30.9–43.2] | ||||
Fitted models included adjustment for age, sex, race, study, education, drinking status, drinking intensity, and drinking duration. The reference category was defined as “Never smokers”. The reference category included 2,791 cases and 13,139 controls for the analysis on oral and pharyngeal cancer and 330 cases and 11,433 controls for that on laryngeal cancer.
Min and Max represent the lowest and the highest OR values estimated for any combinations of intensity and duration by bivariate spline models.