Overview of the Lost City Methanosarcinales (LCMS) methanogenic pathway and membrane-bound complexes involved in energy conservation. Abbreviations: CODH/ACS, carbon monoxide dehydrogenase/acetyl-CoA synthase; Mbh, membrane-bound hydrogenase; Nif, nitrogenase; Mtr, methyl-H4MPT, coenzyme M methyltransferase; Mta, methanol:5-hydroxybenzimidazolylcobamide methyltransferase; Fpo, F420H2 dehydrogenase; MPh, methanophenazine; Hdr, heterodisulfide reductase; ferredoxinrd, reduced ferredoxin.