Figure 3: (Super-)molecular structural properties that define dense phases.

Clockwise from the top: (1) What are the conformations adopted in phase separation-mediating contacts and what is the rearrangement of building blocks relative to each other (also see Figure 1)? (2) Do the stabilities of folded protein domains differ between the dilute and dense phase? And are the affinities between domains and motifs different between the phases? (3) What is the extent of ordering inside of droplets? (4) What are the lifetimes of individual interactions within the dense phase? (5) Over what distance within the dense phase is the movement of building blocks correlated? (6) How many cross-links form between molecules in the dense phase and what is the resulting mesh size? (7) Do the structures of molecules and their assemblies differ between the bulk dense phase and the phase boundary with the dilute phase?