Table 2.

Odds ratios and corresponding 95% confidence intervals for personal history factors as predictors of BRCA1 and BRCA2 pathogenic variant carrier status

	BRCA1				BRCA2
Phenotype	Caucasian	African American	Asian	Hispanic	Caucasian	African American	Asian	Hispanic
DCIS	1.0 (0.7, 1.3)	0.2 (0.0, 1.2)	0.8 (0.2, 2.6)	0.6 (0.2, 2.0)	1.3 (1.1, 1.6)	0.9 (0.4, 1.9)	0.5 (0.2, 1.2)	1.6 (0.9, 3.1)
TN + dx <50	15.9 (13.4, 18.9)	15.7 (9.8, 25.2)	23.5 (10.9, 50.6)	25.9 (15.7, 42.8)	3.1 (2.3, 4.0)	3.4 (1.9, 5.9)	1.5 (0.5, 4.3)	2.1 (0.9, 4.9)
TN + dx ≥50	5.1 (4.2, 6.3)	2.8 (1.4, 5.4)	9.0 (3.1, 26.6)	4.6 (2.2, 10.0)	2.9 (2.3, 3.7)	1.5 (0.7, 2.9)	1.9 (0.7, 5.6)	0.9 (0.3, 3.0)
TN – dx <50	1.7 (1.4, 2.1)	2.5 (1.5, 4.2)	3.1 (1.5, 6.1)	2.9 (1.7, 4.9)	2.5 (2.1, 2.9)	2.4 (1.5, 3.9)	1.0 (0.6, 1.8)	2.0 (1.2, 3.3)
TN – dx ≥50	0.5 (0.4, 0.7)	0.5 (0.2,1.5)	1.3 (0.5, 3.6)	0.7 (0.2, 2.0)	1.5 (1.2, 1.7)	1.4 (0.8, 2.5)	0.9 (0.4, 1.8)	1.8 (1.0, 3.2)
TN . dx <50	3.8 (3.2, 4.5)	5.4 (3.3, 9.0)	4.2 (1.9, 9.1)	4.8 (2.9, 8.1)	2.4 (2.0, 2.8)	3.2 (1.9, 5.2)	0.9 (0.4, 1.9)	1.8 (1.0, 3.2)
TN . dx ≥50	1.1 (0.9, 1.4)	1.2 (0.5, 3.1)	2.0 (0.6, 6.0)	–	1.4 (1.2, 1.8)	1.4 (0.7, 2.8)	1.2 (0.5, 2.9)	1.2 (0.5,2.9)
Bilateral BC	1.6 (1.3, 1.9)	1.8 (1.2, 2.8)	1.7 (0.8, 3.4)	2.2 (1.2, 3.9)	1.2 (1.0, 1.5)	2.0 (1.4, 3.1)	0.8 (0.3, 1.9)	1.1 (0.5, 2.2)
OV <60	10.7 (9.2, 12.4)	8.6 (4.7, 15.7)	17.2 (8.7, 34.0)	17.5 (10.6, 28.8)	4.0 (3.3, 4.8)	3.0 (1.5, 6.2)	1.4 (0.6, 3.3)	3.9 (2.1, 7.1)
OV ≥60	4.2 (3.4, 5.2)	1.1 (0.1, 7.9)	12.0 (4.9, 29.2)	14.1 (7.3, 27.4)	4.9 (4.1, 5.8)	4.3 (2.0, 9.4)	4.7 (2.2, 10.0)	2.6 (1.0, 6.8)
Pancreatic	1.3 (0.8, 2.3)	2.3 (0.5, 10.3)	–	–	3.9 (3.0, 5.2)	2.4 (0.8, 7.3)	5.1 (1.8, 14.7)	6.3 (2.4, 17.0)
Male BC	1.1 (0.4, 3.1)	–	–	–	6.3 (4.6, 8.6)	4.0 (1.6, 10.2)	1.8 (0.2, 15.6)	5.6 (1.2, 26.1)
Pr Ca<60	1.1 (0.3, 4.3)	–	–	–	1.4 (0.6, 3.2)	3.2 (0.4, 27.1)	–	10.3 (1.2, 87.6)
Pr Ca≥60	1.9 (0.7, 5.1)	–	–	–	2.4 (1.4, 4.1)	9.7 (1.8, 51.4)	5.1 (0.5, 58.9)	16.3 (3.2, 83.8)

BC breast cancer, DCIS ductal carcinoma in situ, TN triple negative.