Table 3.
Odds ratios and corresponding 95% confidence intervals for family history predictors of BRCA1 and BRCA2 pathogenic variant carrier status
| No. of 1st/2nd relatives | BRCA1 | BRCA2 | ||||||
|---|---|---|---|---|---|---|---|---|
| With BC <50 (vs. 0) | Caucasian | African American | Asian | Hispanic | Caucasian | African American | Asian | Hispanic |
| 1 | 2.2 (2.0, 2.4) | 3.1 (2.2, 4.4) | 2.8 (1.7, 4.5) | 2.7 (1.9, 3.9) | 1.5 (1.3, 1.7) | 1.3 (0.9, 1.8) | 1.3 (0.8, 2.0) | 1.5 (1.0, 2.2) |
| 2 | 3.7 (3.1, 4.4) | 5.1 (3.2, 8.2) | 3.0 (1.3, 7.2) | 5.0 (2.9, 8.7) | 2.0 (1.6, 2.4) | 1.4 (0.8, 2.4) | 1.5 (0.7, 3.5) | 1.3 (0.7, 2.7) |
| 3+ | 5.3 (4.0, 7.0) | 12.0 (6.5, 22.1) | 8.3 (2.2, 32.1) | 9.1 (4.4, 18.9) | 3.2 (2.4, 4.3) | 1.8 (0.7, 4.5) | 3.1 (0.7, 13.9) | 3.4 (1.4, 8.2) |
| BC ≥50 (vs. 0) | ||||||||
| 1 | 0.9 (0.8, 1.1) | 0.7 (0.5, 1.0) | 1.5 (0.9, 2.3) | 1.1 (0.7, 1.5) | 1.1 (0.9, 1.2) | 0.8 (0.6, 1.2) | 2.4 (1.6, 3.6) | 1.3 (0.9, 1.9) |
| 2 | 0.7 (0.6, 0.8) | 0.5 (0.2, 1.0) | 0.6 (0.2, 2.0) | 0.7 (0.4, 1.4) | 0.9 (0.8, 1.1) | 0.8 (0.5, 1.3) | 1.4 (0.6, 3.0) | 0.9 (0.5, 1.7) |
| 3+ | 0.7 (0.5, 1.0) | 0.7 (0.2, 1.9) | 2.0 (0.4, 8.8) | 0.9 (0.3, 2.7) | 0.7 (0.6, 1.0) | 1.4 (0.7, 2.6) | 3.0 (1.1, 7.8) | 0.4 (0.1, 1.6) |
| OC <60 (vs. 0) | ||||||||
| 1 | 3.2 (2.8, 3.7) | 1.7 (1.0, 2.9) | 3.4 (1.9, 6.2) | 1.9 (1.2, 2.9) | 1.4 (1.2, 1.7) | 2.1 (1.3, 3.2) | 1.5 (0.8, 2.8) | 1.4 (0.8, 2.2) |
| 2+ | 5.4 (4.1, 7.1) | 0.4 (0.0, 2.9) | 4.8 (1.2, 19.1) | 3.0 (1.4, 6.6) | 1.4 (0.9, 2.1) | 0.6 (0.1, 4.2) | 1.0 (0.1, 7.6) | 1.0 (0.3, 3.4) |
| OC ≥60 (vs. 0) | ||||||||
| 1 | 1.7 (1.4, 2.0) | 2.3 (1.2, 4.1) | 1.8 (0.8, 4.1) | 1.9 (1.0, 3.6) | 1.6 (1.3, 1.8) | 0.7 (0.3, 1.5) | 1.2 (0.6, 2.6) | 1.5 (0.8, 2.9) |
| 2+ | 1.6 (0.9, 2.8) | 2.7 (0.6, 12.5) | 5.6 (1.3, 25.0) | 2.0 (0.3, 15.4) | 1.9 (1.2, 3.0) | 1.0 (0.1, 7.1) | – | 1.6 (0.4, 7.0) |
| Pancreatic cancer | ||||||||
| 1 | 1.1 (0.9, 1.3) | 0.9 (0.5, 1.6) | 0.7 (0.2, 1.9) | 1.2 (0.7, 2.3) | 1.3 (1.1, 1.5) | 1.6 (1.0, 2.5) | 1.7 (0.9, 3.1) | 2.1 (1.3, 3.3) |
| 2+ | 0.7 (0.4, 1.1) | 2.0 (0.7, 5.5) | 1.3 (0.2, 10.0) | 2.6 (1.0, 6.6) | 1.7 (1.3, 2.2) | 1.1 (0.3, 3.6) | 0.6 (0.1, 4.5) | 0.4 (0.1, 2.9) |
| MBC | 1.0 (0.7, 1.5) | 0.9 (0.2, 3.7) | – | 0.4 (0.0, 3.1) | 2.5 (1.9, 3.1) | 5.4 (3.0, 9.7) | – | 3.1 (1.3, 7.5) |
| Prostate (vs. 0) | ||||||||
| 1 | 0.9 (0.8, 1.1) | 0.4 (0.2, 0.7) | 0.9 (0.4, 1.9) | 0.8 (0.5, 1.3) | 1.3 (1.2, 1.5) | 1.2 (0.8, 1.7) | 1.8 (1.1, 3.0) | 1.3 (0.8, 2.0) |
| 2+ | 0.7 (0.5, 0.9) | 0.5 (0.2, 1.1) | 0.5 (0.1, 4.3) | 0.4 (0.1, 1.4) | 1.5 (1.3, 1.8) | 0.9 (0.5, 1.6) | 1.9 (0.6, 6.7) | 2.1 (1.1, 3.9) |
| Total model AUC | 0.79 (0.77–0.80) | 0.83 (0.80–0.86) | 0.79 (0.74–0.83) | 0.82 (0.79–0.85) | 0.67 (0.66–0.69) | 0.68 (0.64–0.72) | 0.70 (0.65–0.75) | 0.66 (0.62–0.71) |
AUC area under the curve, BC breast cancer, MBC male breast cancer, OC ovarian cancer.