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Effect of reference region-based analysis on the in vivo [11C]ITDM quantification. Relative quantification using pons as reference region resulted in contradictory results with higher binding potential in WT mice compared to HET littermates. Data at 16 months of age are reported. **p < 0.01, ***p < 0.001. WT = wild-type, HET = heterozygous, CB = cerebellum, THAL = thalamus, STR = striatum, MC = motor cortex, HC = hippocampus
