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. 2019 Dec 26;57(4):1904–1916. doi: 10.1007/s12035-019-01860-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Effect of ASDs on epileptiform-like discharges recorded from the optic tectum of 4 dpf cacna1aa and Ctrl-MO morphants. Larvae were incubated (2 h) with different ASDs. Results are presented as a number of events, b mean duration of events (msec), and c cumulative duration of events (msec) during 20 min of recording. Statistical analysis was performed using one-way ANOVA with Tukey’s post-hoc test. Dots represent individual measurements, the central horizontal mark is the mean, and error bars represent SD (n = 9–25). Symbols represent following comparisons: *P < 0.05 vs Ctrl-MO group incubated with Veh, ^#P < 0.05 vs cacna1aa MOs group incubated with Veh. CBZ, carbamazepine (100 μM); ETX, ethosuximide (10 mM), LTG, lamotrigine (200 μM), TPR, topiramate (100 μM), VPA, sodium valproate (100 μM)