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. 2020 Apr 2;11(4):215. doi: 10.1038/s41419-020-2409-0

Fig. 6. NSCLC cells derived exosomes deliver UFC1 to promote NSCLC progression by downregulating PTEN.

Fig. 6

a QRT-PCR analysis of UFC1 expression in A549 cells treated with PBS, exosomes-depleted conditioned medium (Ex-depleted CM), exosomes from sh-Ctrl and sh-UFC1 transfected A549 cells. b–e Cell counting (b), colony formation (c), transwell migration (d), and matrigel invasion (e) assays for A549 cells treated with PBS, Ex-depleted CM, or exosomes from sh-Ctrl and sh-UFC1 transfected A549 cells. f QRT-PCR and western blot analysis of PTEN expression in A549 cells treated with PBS, Ex-depleted CM, or exosomes from sh-Ctrl and sh-UFC1 transfected A549 cells. The experiments were repeated for three times. Scale bar: 100 μm. *P < 0.05, **P < 0.01, ***P < 0.001, compared to PBS group; #P < 0.05, ##P < 0.01, ###P < 0.001, compared to A549 Ex group; #P < 0.05, ##P < 0.01, ###P < 0.001, compared to sh-Ctrl Ex group.