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. 2020 Apr 2;3:157. doi: 10.1038/s42003-020-0844-1

Fig. 6. GEE models show genotype alone and genotype combined with lifestyle affects PAL performance in TwinsUK cohort.

Fig. 6

a, b Tukey’s boxplots showing significant associations between the rs497849 (a) and rs782431 (b) genotype with PAL errors. c Tukey boxplot showing the lack of association between rs10997817 genotype with PAL errors and d scatterplot showing the interaction of rs10997817 genotype on the association between physical activity (IPAQ) and PAL errors. Together, (c) and (d) show that while there is no significant association between rs10997817 genotype and physical activity, the association between physical activity and PAL errors is modulated by the individual’s genotype for the rs10997817 SNP. e Tukey boxplot showing the lack of association between rs9642563 genotype and PAL errors and f scatterplot showing the significant interaction of rs9642563 genotype on the association between adherence to Mediterranean diet (MDS) and PAL errors. As above, (e) and (f) show that while there is no significant association between rs9642563 genotype and MDS, the association between MDS and PAL errors is modulated by the individual’s genotype for the rs9642563 SNP. Data were analysed as categorical but represented as continuous for ease of visualisation. Genotypes are displayed as 0: homozygous for the major allele (orange), 1: heterozygous (green) and 2: homozygous for the minor allele (blue).