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Analysis of CRC spheroid response to ASA and MET treatment. (A) Quantification of CRC spheroid core size in a cohort of eight patients. (B) Quantification of 3D migration region for CRC spheroids (n = 8) (*P < 0.05; ***P < 0.0005). (C) Representative bright-field images of spheroids from one patient at day 7 (scale bar 200 μm) (− = control; M = MET; A = ASA; C = ASA/MET combination).
