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. 2020 Mar 27;11:364. doi: 10.3389/fphar.2020.00364

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Copyright © 2020 Bai, Peng, Yang, Zou, Liu, Wu, Fan, Li, Zeng and Su

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma level-time curves for naringin and naringenin after oral administration (p.o.) of naringin at different doses in rats, dogs, and humans (n=10 per group of rats, n=6 per group of dogs, n=8 per group of humans, mean ± SE). The PK profiles were presented as follows: naringin (A) and naringenin (B) PK profiles of naringin (10.5, 21, 42, and 168 mg kg-1) in rats; naringin (C) and naringenin (D) PK profiles of naringin (3.1, 12.4, and 49.6 mg kg-1) in dogs; naringin (E) and naringenin (F) PK profiles of naringin (40, 80, 160, 320, and 480 mg) in humans.