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. 2020 Mar 27;11:371. doi: 10.3389/fphar.2020.00371

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Copyright © 2020 Piirsalu, Taalberg, Lilleväli, Tian, Zilmer and Vasar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic overview of the experimental design. Male mice on a Bl6 (n = 56) and 129Sv (n = 56) background were used in this study. Mice from both strains were randomly assigned to three different experimental groups: cohort 1 was used to determine the effect of LPS on locomotor activity (Bl6 n = 16; 129Sv n = 16); cohort 2 was used to study the effect of LPS on the profile of blood metabolites after 1.5 h treatment (Bl6 n = 20; 129Sv n = 20); cohort 3 was used to study the effect of LPS on the profile of blood metabolites after 24 h treatment (Bl6 n = 20; 129Sv n = 20). In each cohort, both strains were further divided into two groups: LPS administration group and control group (saline administration).