Table 3.
Alterations of DMN NH across patients (at baseline, after 8 weeks of treatment) and controls.
| Cluster location | Peak coordinate | Cluster (voxel) |
T value | ||
|---|---|---|---|---|---|
| x | y | Z | |||
| DPP group at baseline vs controls | |||||
| Right Cerebellum Crus II | 24 | -75 | -39 | 20 | 3.661 |
| Bilateral ventral MPFC | 0 | 54 | -6 | 58 | -3.3422 |
| Right PCC/Precuneus | 15 | -48 | 3 | 65 | -6.3186 |
| Bilateral superior MPFC | -3 | 48 | 54 | 26 | 3.4227 |
| DT group at baseline vs controls | |||||
| Bilateral ventral MPFC | -3 | 54 | -9 | 53 | -3.8297 |
| Right PCC/Precuneus | 9 | -45 | 9 | 38 | -4.1595 |
| Bilateral Precuneus | 3 | -63 | 51 | 75 | -3.7244 |
| Bilateral superior MPFC | -3 | 42 | 51 | 23 | 3.1693 |
| DPP group after 8 weeks vs at baseline | |||||
| Right PCC/Precuneus | 15 | -48 | 6 | 21 | 3.1264 |
| DT group after 8 weeks vs at baseline | |||||
| No cluster | |||||
| DPP group vs DT group after 8 weeks | |||||
| Bilateral Precuneus | 3 | -66 | 51 | 24 | 3.3257 |
| DPP group vs DT group at baseline | |||||
| No cluster | |||||
The significance level was set at p < 0.05 corrected by the Gaussian random field (GRF) theory (voxel significance: p < 0.001, cluster significance: p < 0.05) for multiple comparisons with the REST software (age and mean FD as covariates). MPFC, medial prefrontal cortex; PCC, posterior cingulate cortex; FD, framewise displacement.