Table 3.
Comparison between insulin sensitivity tertiles
| Low IS (n = 14) | Mid IS (n = 15) | High IS (n = 14) | P value | |||
|---|---|---|---|---|---|---|
| Low vs. mid | Mid vs. high | Low vs. high | ||||
| M value, mg/kglean/min | 2.6 ± 0.9 | 5.2 ± 0.6 | 9.0 ± 2.0 | <0.001 | <0.001 | <0.001 |
| BMI, kg/m2 | 33.3 ± 3.8 | 30.7 ± 3.9 | 29.5 ± 3.3 | n.s. | n.s. | 0.027 |
| SBP, mmHg* | 145 ± 14 | 141 ± 17 | 150 ± 18 | n.s. | n.s. | n.s. |
| DBP, mmHg | 89 ± 8 | 83 ± 8 | 82 ± 6.1 | n.s. | n.s. | n.s. |
| GFR, mL/min | 129 ± 26 | 100 ± 20 | 103 ± 21 | 0.003 | n.s. | 0.010 |
| ERPF, mL/min* | 551 ± 105 | 464 ± 108 | 488 ± 107 | n.s. | n.s. | n.s. |
| FF, % | 23.3 ± 2.7 | 22.3 ± 2.4 | 20.7 ± 2.8 | n.s. | n.s. | 0.039 |
| ERBF, mL/min* | 953 ± 193 | 786 ± 207 | 807 ± 189 | n.s. | n.s. | n.s. |
| RVR, mmHg/L/min* | 117 ± 24 | 139 ± 37 | 136 ± 34 | n.s. | n.s. | n.s. |
| Albuminuria, mg/day*# | 13.5 (9.0–64.5) | 8.0 (3.3–13.3) | 11.0 (6.5–18.1) | n.s. | n.s. | n.s. |
Values are expressed as mean ± SD or median (IQR) when nonparametric. Clinical characteristics and renal measures compared across tertiles of insulin sensitivity (IS) (lean M value). When one-way ANOVA was significant, individual tertiles were compared using the Bonferroni post hoc test. n.s., nonsignificant.
*
One-way ANOVA test nonsignificant, and individual tertiles were thus not compared.
#
Analyzed after ln-transformation. Significant differences indicated in boldface type.