Fig. 2.

The molecular architecture of TMEM16A. (a-b) Cartoon representation of overlap of the Ca²⁺-bound structure of TMEM16A channel (cyan) with lipid scrambler (nhTMEM16; gray). (c) The pore domain of TMEM16A, the pores are shown by a gray grid. (d) Ca²⁺ binding sites. (e) PI(4,5)P₂ binding sites. For the sake of clarity, key amino acids are marked as sticks and only the amino acids that can be displayed on this side are shown. (f) Electrostatic surface of TMEM16A. Red (−50 kT/e); blue (+50 kT/e). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)