Figure 5.

Restoration of Phe and 5-HIAA Levels in the Brain of Pah^enu2 Mice

(A) Tryptophan metabolic pathway leading to the formation of 5-HIAA. (B) Brain levels of the serotonin metabolite 5-HIAA in vehicle or AAVHSC15-treated Pah^enu2 mice and parental BTBR mice. Brain 5-HIAA levels were determined as described in Materials and Methods. (C) Brain Phe levels in the brain tissue of vehicle- or AAVHSC15-treated Pah^enu2 and parental BTBR mice. Statistically significant differences were determined by the Students’ t test. p < 0.0001, vehicle versus AAVHSC15-PAH treated PAH^enu2 mice.