Table 1.
Baseline characteristics by age at natural menopause and incident cardiovascular disease events
|
Age at natural menopause |
Incident cardiovascular disease |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Premenopausal or perimenopausal (n=108 913) | <40 years (n=3424) | 40–44 years (n=14 038) | 45–49 years (n=48 061) | 50–51 years (n=47 391) | 52–54 years (n=50 996) | ≥55 years (n=28 662) | No (n=287 231) | Yes (n=14 254) | |
| Ethnicity | |||||||||
| White Australian or New Zealander | 351 (0·3%) | 300 (8·8%) | 1084 (7·7%) | 3451 (7·2%) | 3552 (7·5%) | 3655 (7·2%) | 2258 (7·9%) | 12 974 (4·5%) | 1677 (11·8%) |
| White European | 65 402 (60·1%) | 2905 (84·8%) | 12 070 (86·0%) | 40 410 (84·1%) | 40 178 (84·8%) | 43 924 (86·1%) | 25 073 (87·5%) | 218 482 (76·1%) | 11 480 (80·5%) |
| White American or Canadian | 476 (0·4%) | 7 (0·2%) | 47 (0·3%%) | 382 (0·8%) | 404 (0·9%) | 497 (1·0%) | 177 (0·6%) | 1893 (0·7%) | 97 (0·7%) |
| Asian | 39 729 (36·5%) | 131 (3·8%) | 510 (3·6%) | 2669 (5·6%) | 2376 (5·0%) | 2073 (4·1%) | 711 (2·5%) | 47 626 (16·6%) | 573 (4·0%) |
| Black | 1844 (1·7%) | 53 (1·6%) | 212 (1·5%) | 740 (1·5%) | 535 (1·1%) | 522 (1·0%) | 293 (1·0%) | 3920 (1·4%) | 279 (2·0%) |
| Other | 1111 (1·0%) | 28 (0·8%) | 115 (0·8%) | 409 (0·9%) | 346 (0·7%) | 325 (0·6%) | 150 (0·5%) | 2336 (0·8%) | 148 (1·0%) |
| Body-mass index | |||||||||
| Underweight (<18·5 kg/m2) | 6332 (5·8%) | 108 (3·2%) | 326 (2·3%) | 1135 (2·4%) | 963 (2·0%) | 836 (1·6%) | 374 (1·3%) | 9694 (3·4%) | 380 (2·7%) |
| Normal (18·5–24·9 kg/m2) | 65 785 (60·4%) | 1392 (40·7%) | 5959 (42·5%) | 22 259 (46·3%) | 22 000 (46·4%) | 22 741 (44·6%) | 11 004 (38·4%) | 146 008 (50·8%) | 5132 (36·0%) |
| Overweight (25·0–29·9 kg/m2) | 24 082 (22·1%) | 1113 (32·5%) | 4873 (34·7%) | 15 835 (33·0%) | 15 969 (33·7%) | 17 848 (35·0%) | 10 936 (38·2%) | 85 840 (29·9%) | 4816 (33·8%) |
| Obese (≥30 kg/m2) | 12 714 (11·7%) | 811 (23·7%) | 2880 (20·5%) | 8832 (18·4%) | 8459 (17·9%) | 9571 (18·8%) | 6348 (22·2%) | 45 689 (15·9%) | 3926 (27·5%) |
| Smoking status | |||||||||
| Never | 69 794 (64·1%) | 1709 (49·9%) | 7172 (51·1%) | 25 829 (53·7%) | 27 472 (58·0%) | 30 492 (59·8%) | 17 372 (60·6%) | 173 013 (60·2%) | 6827 (47·9%) |
| Past smoker | 24 003 (22·0%) | 1080 (31·5%) | 4565 (32·5%) | 15 049 (31·3%) | 14 809 (31·3%) | 15 980 (31·3%) | 9382 (32·7%) | 79 928 (27·8%) | 4940 (34·7%) |
| Current smoker | 15 116 (13·9%) | 635 (18·6%) | 2301 (16·4%) | 7183 (15·0%) | 5110 (10·8%) | 4524 (8·9%) | 1908 (6·7%) | 34 290 (11·9%) | 2487 (17·5%) |
| Education level (years) | |||||||||
| ≤10 | 24 475 (22·5%) | 1926 (56·3%) | 7367 (52·5%) | 22 204 (46·2%) | 21 860 (46·1%) | 22 896 (44·9%) | 14 195 (49·5%) | 107 353 (37·4%) | 7570 (53·1%) |
| 11–12 | 13 367 (12·3%) | 410 (12·0%) | 1546 (11·0%) | 5483 (11·4%) | 5575 (11·8%) | 6293 (12·3%) | 3297 (11·5%) | 34 446 (12·0%) | 1525 (10·7%) |
| >12 | 71 071 (65·3%) | 1088 (31·8%) | 5125 (36·5%) | 20 374 (42·4%) | 19 956 (42·1%) | 21 807 (42·8%) | 11 170 (39·0%) | 145 432 (50·6%) | 5159 (36·2%) |
| Age at last follow-up (years) | |||||||||
| <60 | 108 913 (100%) | 1724 (50·4%) | 6329 (45·1%) | 24 334 (50·6%) | 21 373 (45·1%) | 21 785 (42·7%) | 6654 (23·2%) | 187 134 (65·2%) | 3951 (27·7%) |
| 60–64 | .. | 794 (23·2%) | 3573 (25·5%) | 11 009 (22·9%) | 12 942 (27·3%) | 15 570 (30·5%) | 12 176 (42·5%) | 52 808 (18·4%) | 3281 (23·0%) |
| 65–69 | .. | 612 (17·9%) | 2877 (20·5%) | 8750 (18·2%) | 9214 (19·4%) | 9744 (19·1%) | 7792 (27·2%) | 35 282 (12·3v) | 3709 (26·0%) |
| ≥70 | .. | 294 (8·6%) | 1259 (9·0%) | 3968 (8·3%) | 3862 (8·2%) | 3897 (7·6%) | 2040 (7·1%) | 12 007 (4·2%) | 3313 (23·3%) |
| Hypertension | |||||||||
| No | 99 482 (91·3%) | 2581 (75·4%) | 10 494 (74·8%) | 37 069 (77·1%) | 35 968 (75·9%) | 38 137 (74·8%) | 20 165 (70·4%) | 236 457 (82·3%) | 7439 (52·2%) |
| Yes | 9431 (8·7%) | 843 (24·6) | 3544 (25·3%) | 10 992 (22·9%) | 11 423 (24·1%) | 12 859 (25·2%) | 8497 (29·7%) | 50 774 (17·7%) | 6815 (47·8%) |
| Postmenopausal menopausal hormone therapy | |||||||||
| No | 105 459 (96·8%) | 1478 (43·2%) | 7202 (51·3%) | 29 284 (60·9%) | 30 232 (63·8%) | 32 597 (63·9%) | 16 194 (56·5%) | 213 791 (74·4%) | 8655 (60·7%) |
| Yes | 3454 (3·25) | 1946 (56·8%) | 6836 (48·7%) | 18 777 (39·1%) | 17 159 (36·2%) | 18 399 (36·1%) | 12 468 (43·5%) | 73 440 (25·6%) | 5599 (39·3%) |
| Number of children | |||||||||
| 0 | 27 897 (26·1%) | 756 (22·5%) | 2668 (19·2%) | 8879 (18·7%) | 7795 (16·6%) | 7337 (14·5%) | 3574 (12·6%) | 56 880 (20·1%) | 2026 (14·5%) |
| 1 | 15 038 (14·1%) | 517 (15·4%) | 1992 (14·4%) | 6365 (13·4%) | 5752 (12·3%) | 5892 (11·7%) | 3136 (11·0%) | 36 853 (13·0%) | 1839 (13·1%) |
| 2 | 40 623 (38·0%) | 1238 (36·9%) | 5513 (39·8%) | 19 768 (41·7%) | 20 249 (43·2%) | 22 594 (44·7%) | 13 086 (46·0%) | 117 824 (41·6%) | 5247 (37·4%) |
| ≥3 | 23 410 (21·9%) | 849 (25·3%) | 3695 (26·6%) | 12 439 (26·21%) | 13 107 (27·9%) | 14 733 (29·1%) | 8663 (30·4%) | 71 988 (25·4%) | 4908 (35·0%) |
| Age at menarche (years) | |||||||||
| ≤11 | 20 331 (19·1%) | 764 (23·1%) | 2818 (20·8%) | 8296 (17·9%) | 7837 (17·1%) | 8577 (17·4%) | 5328 (19·2%) | 51 338 (18·4%) | 2613 (19·4%) |
| 12 | 25 699 (24·1%) | 577 (17·4%) | 2537 (18·7%) | 8992 (19·4%) | 8898 (19·5%) | 9753 (19·7%) | 5139 (18·5%) | 59 143 (21·2%) | 2452 (18·2%) |
| 13 | 27 900 (26·1%) | 742 (22·4%) | 3138 (23·1%) | 11 777 (25·4%) | 11 809 (25·8%) | 12 838 (26·0%) | 6698 (24·1%) | 71 753 (25·7%) | 3149 (23·4%) |
| 14 | 19 945 (18·7%) | 612 (18·5%) | 2700 (19·9%) | 9430 (20·3%) | 9495 (20·8%) | 10 350 (21·0%) | 5693 (20·5%) | 55 501 (19·9%) | 2724 (20·2%) |
| ≥15 | 12 871 (12·1%) | 613 (18·5%) | 2368 (17·5%) | 7914 (17·0%) | 7694 (16·8%) | 7919 (16·0%) | 4968 (17·9%) | 41 816 (15·0%) | 2531 (18·8%) |
Data are n (%).