Table 2.

Associations between age at natural menopause and first non-fatal cardiovascular disease, coronary heart disease, and stroke events

		Women (n)	Cardiovascular disease events (n)	Person-years (n)	Events per 1000 person-years (n)	Adjusted HR (95% CI)*
Cardiovascular disease
Age at natural menopause (years)
	<40	3424	346	84 961·6	4·1	1·55 (1·38–1·73)
	40–44	14 038	1216	372 142·8	3·3	1·30 (1·22–1·39)
	45–49	48 061	3316	1 269 834·9	2·6	1·12 (1·07–1·18)
	50–51	47 391	3016	1 303 876·1	2·3	1 (ref)
	52–54	50 996	3146	1 429 883·3	2·2	0·96 (0·91–1·01)
	≥55	28 662	1922	852 776·4	2·3	0·88 (0·83–0·93)
	Premenopause or perimenopause	108 913	3253	2 842 537·1	1·1	0·52 (0·48–0·56)
Trend p value†		..	..	..	..	<0·0001
Coronary heart disease
Age at natural menopause (years)
	<40	3419	253	85 414·1	3·0	1·52 (1·34–1·74)
	40–44	14 022	881	373 417·4	2·4	1·30 (1·20–1·41)
	45–49	48 016	2418	1 272 920·1	1·9	1·13 (1·06–1·20)
	50–51	47 362	2180	1 307 497·1	1·7	1 (ref)
	52–54	50 944	2260	1 432 324·2	1·6	0·96 (0·90–1·02)
	≥55	28 628	1377	854 420·9	1·6	0·90 (0·85–0·97)
	Premenopause or perimenopause	108 902	2229	2 710 689·7	0·8	0·59 (0·53–0·65)
Trend p value†		..	..	..	..	<0·0001
Stroke
Age at natural menopause (years)
	<40	3412	126	86 474·8	1·5	1·72 (1·43–2·07)
	40–44	13 993	416	376 099·8	1·1	1·32 (1·18–1·48)
	45–49	47 892	1078	1 279 465·0	0·8	1·09 (1·00–1·18)
	50–51	47 301	1018	1 31 4206·0	0·8	1 (ref)
	52–54	50 868	1048	1 439 717·0	0·7	0·94 (0·86–1·02)
	≥55	28 644	652	860 938·3	0·8	0·89 (0·81–0·99)
	Premenopause or perimenopause	108 805	1120	2 065 658·4	0·5	0·46 (0·40–0·52)
Trend p value†		..	..	..	..	<0·0001

HR=hazard ratio.

^*Cox proportional hazards models were used to estimate HRs and 95% CIs. All HRs were adjusted for age at last follow-up, ethnicity, education level, body-mass index, smoking status, hypertension status, and postmenopausal menopausal hormone therapy status, or oral contraception use in the premenopause or perimenopause group.

^†χ² values of >50, with 6 degrees of freedom.