Table 3.
Associations between age at natural menopause and age at first cardiovascular disease, coronary heat disease, and stroke events*
|
Aged <60 years at first event |
Aged 60–69 years at first event |
Aged ≥70 years at first event |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular disease events (n) | Events per 1000 person-years (n) | Adjusted HR (95% CI) | Cardiovascular disease events (n) | Events per 1000 person-years (n) | Adjusted HR (95% CI) | Cardiovascular disease events (n) | Events per 1000 person-years (n) | Adjusted HR (95% CI) | ||
| Cardiovascular disease | ||||||||||
| Age at natural menopause (years) | ||||||||||
| <40 | 193 | 2·5 | 1·88 (1·62–2·20) | 99 | 2·0 | 1·35 (1·10–1·66) | 54 | 3·9 | 1·14 (0·86–1·52) | |
| 40–44 | 597 | 1·8 | 1·40 (1·27–1·54) | 413 | 1·8 | 1·30 (1·16–1·46) | 206 | 3·2 | 1·09 (0·93–1·27) | |
| 45–49 | 1634 | 1·4 | 1·17 (1·09–1·25) | 1035 | 1·4 | 1·08 (0·99–1·17) | 647 | 3·2 | 1·09 (0·97–1·22) | |
| 50–51 | 1472 | 1·3 | 1 (ref) | 986 | 1·2 | 1 (ref) | 558 | 2·7 | 1 (ref) | |
| 52–54 | 1523 | 1·2 | 0·91 (0·85–0·98) | 1065 | 1·2 | 0·99 (0·91–1·08) | 558 | 2·8 | 1·02 (0·91–1·15) | |
| ≥55 | 875 | 1·2 | 0·82 (0·75–0·89) | 729 | 1·1 | 0·91 (0·83–1·00) | 318 | 2·8 | 1·07 (0·93–1·23) | |
| Trend p value | .. | .. | <0·0001 | .. | .. | <0·0001 | .. | .. | 0·0342 | |
| Coronary heart disease | ||||||||||
| Age at natural menopause (years) | ||||||||||
| <40 | 139 | 1·8 | 1·85 (1·48–2·10) | 79 | 1·5 | 1·44 (1·14–1·81) | 35 | 2·5 | 1·03 (0·73– ·46) | |
| 40–44 | 423 | 1·3 | 1·38 (1·23–1·54) | 307 | 1·3 | 1·33 (1·16–1·52) | 151 | 2·3 | 1·06 (0·88–1·27) | |
| 45–49 | 1195 | 1·1 | 1·19 (1·10–1·30) | 768 | 1·0 | 1·11 (1·00–1·22) | 455 | 2·2 | 1·02 (0·89–1·17) | |
| 50–51 | 1052 | 0·9 | 1 (ref) | 713 | 0·9 | 1 (ref) | 415 | 2·0 | 1 (ref) | |
| 52–54 | 1111 | 0·9 | 0·93 (0·86–1·01) | 763 | 0·9 | 0·99 (0·89–1·10) | 386 | 1·9 | 0·96 (0·84–1·10) | |
| ≥55 | 653 | 0·9 | 0·86 (0·78–0·95) | 522 | 0·8 | 0·92 (0·82–1·03) | 202 | 1·7 | 0·93 (0·79–1·11) | |
| Trend p value | .. | .. | <0·0001 | .. | .. | <0·0001 | .. | .. | 0·0046 | |
| Stroke | ||||||||||
| Age at natural menopause (years) | ||||||||||
| <40 | 62 | 0·8 | 1·93 (1·48–2·52) | 32 | 0·6 | 1·32 (0·91–1·89) | 32 | 2·0 | 1·73 (1·19–2·52) | |
| 40–44 | 199 | 0·6 | 1·44 (1·22–1·70) | 133 | 0·5 | 1·23 (1·01–1·50) | 84 | 1·2 | 1·17 (0·91–1·51) | |
| 45–49 | 509 | 0·4 | 1·11 (0·98–1·26) | 318 | 0·4 | 0·99 (0·85– 1·15) | 251 | 1·2 | 1·15 (0·95–1·38) | |
| 50–51 | 484 | 0·4 | 1 (ref) | 332 | 0·4 | 1 (ref) | 202 | 0·9 | 1 (ref) | |
| 52–54 | 467 | 0·4 | 0·85 (0·75–0·96) | 358 | 0·4 | 0·98 (0·85–1·14) | 223 | 1·0 | 1·10 (0·91–1·33) | |
| ≥55 | 249 | 0·3 | 0·71 (0·60–0·82) | 251 | 0·4 | 0·90 (0·76–1·06) | 152 | 1·2 | 1·38 (1·12–1·71) | |
| Trend p value | .. | .. | <0·0001 | .. | .. | 0·0051 | .. | .. | 0·3826 | |
HR=hazard ratio.
*
Cox proportional hazards models were used to estimate HRs and 95% CIs. All HRs were adjusted for age at last follow-up, ethnicity, education level, body-mass index, smoking status, hypertension status, and postmenopausal menopausal hormone therapy status.