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. 2020 Mar 27;14:62. doi: 10.3389/fncel.2020.00062

Figure 3.

Figure 3

Resveratrol enhanced the engraftment of hUC-MSCs in the brain of Alzheimer’s disease (AD) mice. The hUC-MSCs were identified in the hippocampal sections of AD mice, 6 weeks after completion of cell transplantation, by their immunoreactivity to the human anti-nuclei antibody, MAB1281. (A) Representative immunofluorescent images of MAB1281+ cells in the hippocampus. Scale bar = 50 μm. (B) Quantitative analysis of MAB1281+ cells in the hippocampus. Data were acquired from three mice in each group and from three slides of each mouse hippocampus (n = 9) and were presented as mean ± SEM (t-test: ****indicate p < 0.0001; MSC vs. RES-MSC). (C) Results of polymerase chain reaction (PCR) results of human-specific DNA in the mouse hippocampus. (D) Quantification of human-specific DNA in different groups. Data were acquired from three mice in each group and each experiment was repeated thrice (n = 9) and were expressed as mean ± SEM (t-test: ****indicate p < 0.0001; MSC vs. RES-MSC). MSC, mice treated with mesenchymal stem cells; RES-MSC, mice treated with resveratrol pre-incubated mesenchymal stem cells.