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. 2020 Mar 27;14:62. doi: 10.3389/fncel.2020.00062

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Copyright © 2020 Wang, Wu, Ma, Xie, Liu, Yao, Zhang, Yang, Yang, Guo and Guan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSCs and RES-MSCs down-regulated the phosphorylation of tau in the hippocampus. (A) Representative images of Western Blotting of total MAPT and phospho-Ser396/Thr231/Ser202 MAPT. (B) The gray values were analyzed based on values from three mice in each group and from three independent experiment from each mouse (n = 9). Results were expressed as mean ± SEM. **p < 0.01, ***p < 0.001, ****p < 0.0001 (ANOVA plus Bonferroni: p-Ser396 MAPT: WT vs. AD p < 0.0001, MSC vs. AD p < 0.0001, RES-MSC vs. AD p < 0.0001, MSC vs. RES-MSC p = 0.0002. p-Thr231 MAPT: WT vs. AD p < 0.0001, MSC vs. AD p = 0.0004, RES-MSC vs. AD p < 0.0001, MSC vs. RES-MSC p = 0.002. p-Ser202 MAPT: WT vs. AD p < 0.0001, MSC vs. AD p < 0.0001, RES-MSC vs. AD p < 0.0001, MSC vs. RES-MSC p = 0.0026. MAPT: WT vs. AD p = 0.09981, MSC vs. AD p > 0.9999, RES-MSC vs. AD p > 0.9999, MSC vs. RES-MSC p > 0.9999).