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. 2020 Mar 27;14:62. doi: 10.3389/fncel.2020.00062

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Copyright © 2020 Wang, Wu, Ma, Xie, Liu, Yao, Zhang, Yang, Yang, Guo and Guan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSCs or RES-MSCs inhibited oxidative stress in the hippocampus. Measurement of antioxidant molecules (A) SOD, (B) GSH-Px, and (C) CAT, and the level of (D) MDA in the hippocampus among the experimental groups. Data were collected from 15 mice per group (n = 15). Results were expressed as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 (ANOVA plus Bonferroni: SOD: WT vs. AD p < 0.0001, MSC vs. AD p < 0.0001, RES-MSC vs. AD p < 0.0001, MSC vs. RES-MSC p = 0.0191. GSH-Px: WT vs. AD p < 0.0001, MSC vs. AD p < 0.0001, RES-MSC vs. AD p = 0.0003, MSC vs. RES-MSC p = 0.0062. CAT: WT vs. AD p < 0.0001, MSC vs. AD p < 0.0001, RES-MSC vs. AD p < 0.0001, MSC vs. RES-MSC p = 0.0003. MDA: WT vs. AD p < 0.0001, MSC vs. AD p < 0.0001, RES-MSC vs. AD p < 0.0001, MSC vs. RES-MSC p = 0.0136).