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. 2020 Jan 27;82(3):350–359. doi: 10.1292/jvms.19-0635

Table 2. Combination of blocking reagents and antibodies used for immunohistochemistry.

Detection Blocking reagent Primary antibody Secondary antibody
5-HT Blocking One Histo Rabbit polyclonal antibody against 5-HT EnVision+ System-HRP Labeled Polymer
(Nacalai Tesque, Kyoto, Japan) (20080, 1:80,000) Anti-Rabbit
(ImmunoStar, Hudson, NJ, USA) (Dako, Glostrup, Denmark)

TPH2 Blocking One Histo Rabbit polyclonal antibody against TPH2 EnVision+ System- HRP Labeled Polymer
(Nacalai Tesque, Kyoto, Japan) (PA1-778, 1:4,000) Anti-Rabbit
(Thermo Fisher, Waltham, MA, USA) (Dako, Glostrup, Denmark)

TH Blocking reagent A and B Mouse monoclonal antibody against TH Histofine MAX-PO (M)
(Nichirei Bioscience, Tokyo, Japan) (MAB318; 1:500) (Histofine Simple Stain system)
(Merck Millipore, Darmstadt, Germany) (Nichirei Bioscience, Tokyo, Japan)

5-HT: serotonin, TPH2: tryptphan hydroxylase 2, TH: tyrosine hydroxylase.