Table 2. Ischemic and Bleeding Outcomes of Patients With Acute Coronary Syndrome Associated With Receiving Clopidogrel or Prasugrel, Before and After Propensity Score Matching.
| Outcome | Before matching, No. (%) of events | P value | After matching, No. (%) of events | P value | ||
|---|---|---|---|---|---|---|
| Clopidogrel (n = 1262) | Prasugrel (n = 1297) | Clopidogrel (n = 901) | Prasugrel (n = 901) | |||
| Primary ischemic events | 57 (4.5) | 62 (4.8) | .78 | 33 (3.7) | 46 (5.1) | .17 |
| Death | ||||||
| In-hospital | 49 (3.9) | 50 (3.9) | >.99 | 28 (3.1) | 37 (4.1) | .31 |
| Cardiovascular | 45 (3.6) | 39 (3.0) | .44 | 26 (2.9) | 29 (3.2) | .78 |
| Myocardial infarction | 6 (0.5) | 2 (0.2) | .17 | 3 (0.3) | 2 (0.2) | >.99 |
| Ischemic stroke | 4 (0.3) | 12 (0.9) | .08 | 3 (0.3) | 9 (1.0) | .15 |
| Cardiogenic shock | 31 (2.5) | 30 (2.3) | .90 | 20 (2.2) | 19 (2.1) | >.99 |
| Post heart failure | 36 (2.9) | 33 (2.5) | .72 | 22 (2.4) | 22 (2.4) | >.99 |
| Primary bleeding events | 37 (2.9) | 57 (4.4) | .06 | 16 (1.8) | 45 (5.0) | <.001 |
| Transfusion related to PCI | 25 (2.0) | 38 (2.9) | .12 | 9 (1.0) | 30 (3.3) | <.001 |
| Procedural intervention/surgery | 2 (0.2) | 13 (1.0) | .007 | 2 (0.2) | 9 (1.0) | .07 |
| Bleeding | ||||||
| Puncture site | 12 (1.0) | 15 (1.2) | .70 | 2 (0.2) | 14 (1.6) | .004 |
| Gastrointestinal | 5 (0.4) | 8 (0.6) | .58 | 3 (0.3) | 7 (0.8) | .34 |
| Genitourinary | 1 (0.1) | 2 (0.2) | >.99 | 0 | 2 (0.2) | .50 |
| Other | 21 (1.7) | 30 (2.3) | .26 | 10 (1.1) | 21 (2.3) | .07 |
| TIMI major | 28 (2.2) | 45 (3.5) | .06 | 18 (2.0) | 32 (3.6) | .06 |
| Cerebral | 1 (0.1) | 4 (0.3) | .38 | 1 (0.1) | 2 (0.2) | >.99 |
| TIMI minor | 93 (7.4) | 197 (15.2) | <.001 | 69 (7.7) | 132 (14.7) | <.001 |
| Other outcomes | ||||||
| Acute kidney injury | 189 (15.6) | 189 (14.8) | .58 | 119 (13.8) | 130 (14.7) | .59 |
| De novo dialysis | 18 (1.4) | 21 (1.6) | .75 | 10 (1.1) | 16 (1.8) | .32 |
| Coronary dissection | 5 (0.4) | 3 (0.2) | .50 | 5 (0.6) | 1 (0.1) | .22 |
| Coronary perforation | 3 (0.2) | 5 (0.4) | .73 | 2 (0.2) | 4 (0.4) | .69 |
| CABG after PCI during hospitalization | 10 (0.8) | 10 (0.8) | >.99 | 6 (0.7) | 7 (0.8) | >.99 |
Abbreviations: CABG, coronary artery bypass graft; PCI, percutaneous coronary intervention; TIMI, thrombolysis in myocardial infarction.