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Treatment with Adap-NPs significantly reduces neurodegeneration. (A) IF for ChAT (green) to identify motor neurons in the lumbar spinal cord at 104 (top row) and 143 days of age (bottom row). (B) Quantification of motor neurons in lumbar spinal cord shows progressive loss of motor neurons in spinal cord is reduced with Adap-NP treatment (*p < 0.05, **p < 0.01, ***p < 0.001; two-way ANOVA with Tukey’s post hoc test) n = 12–20 sections per group. Scale bar = 100 μm.
