Figure 2.

Quality-Control Assessments on the MVP Dataset after Performance of the Advanced Marker Quality Control Procedures

(A) MAF distribution after sample QC filtering. The inset diagram shows the distribution for markers with a MAF below 1%.

(B) Minor-allele discordance rates per MAF bin, based on intentionally duplicated samples.

(C) Marker missingness rates per MAF bin, after sample QC filtering.

(D) Comparison of MAFs between the EA subset of MVP (MVP-EUR) and the UK Biobank European subset (UKB-EUR).

(E) Comparison of MAFs between MVP-EUR and the non-Finnish European subset of gnomAD (gnomAD-NFE).