Skip to main content
. 2020 Mar 26;106(4):496–512. doi: 10.1016/j.ajhg.2020.03.002

Figure 4.

Figure 4

Characterization of the Conditional eQTLs

(A and D) Histogram shows the number of eGenes (y axis) that harbor different numbers of independent eQTLs (x axis) in African Americans (A) or European Americans (D). We displayed eGenes that harbor up to nine independent eQTLs, with the detailed number of eQTLs listed above each bar. A large fraction of eGenes harbor a small number of independent eQTLs.

(B and E) The proportion of variance (PVE) in gene expression levels explained by SNPs are higher for eGenes that harbor a larger number of independent eQTLs in African Americans (B) or European Americans (E).

(C and F) Density plot shows the distance from eQTL to the transcription start site (TSS) of the corresponding eGene. The density plot is stratified by the number of eQTLs: eGenes with one independent eQTL is colored in red; eGenes with two independent eQTL is colored in green; eGenes with three independent eQTL is colored in blue; eGenes with four or more independent eQTL is colored in purple. Dashed lines represent the median distance between eQTL and TSS in the four stratified groups in African Americans (C) or European Americans (F).