Figure 2.

Co-localized Regions across Tissues and Cell Types

(A) A typical result from a region with co-localization. Shown is a 100 Kb region, along with the CDTS score (negative values are indicative of constraint) and tissue-specific functional scores (GenoNet). A heatmap of co-localization local fdr shows the co-localization results in this region.

(B) Number of 1 Kb regions with co-localization local fdr $\le 0.3$, for each tissue/cell type in Roadmap.

(C) Jaccard index of overlap between different tissues using regions with co-localization local fdr less than 0.3 in each of 127 tissues/cell types in Roadmap.