FIGURE 1.

Mosquito-borne flaviviruse genome phylogenetic analysis and schematic depiction of the common structural architecture of 5′-3′cirRNA. (A) The maximum-likelihood phylogenetic tree of the MBFVs. Based on the complete-coding-sequence nucleotide alignments, the phylogenetic tree was constructed in MEGA6 with the representative MBFVs in the red box. (B) Structure schematic of the cyclization elements, highlighting the eight MBFVGs and the bird-adaptable MBFVG. The cyclization schematic diagram of NTAV species is lacking because its 3′cis-acting RNA isn’t registered in NCBI. Each element is proportionally scaled and presents as corresponding colors.