Table 2.

Prioritization of radiation for breast cancer based on treatment indication

Tier 1 (high priority for breast RT)	•Inflammatory breast cancer
	•Residual node positivity after NAC
	•4 or more positive nodes (N2)
	•Recurrent disease
	•Node-positive TNBC
	•Extensive LVI
Tier 2 (intermediate priority for breast RT)	•ER+ with 1-3 positive nodes (N1a)
	•Path N0 after NAC
	•LVI (NOS)
	•Node negative TNBC
Tier 3 (low priority for breast RT)	•Early-stage ER+ breast cancer (esp. older)
	•DCIS
	•Otherwise not meeting criteria for tiers 1-2

Abbreviations: DCIS = ductal carcinoma in situ; ER+ = estrogen-receptor positive; LVI = lymphovascular invasion; NAC = neoadjuvant chemotherapy; NOS = not otherwise specified; RT = radiation therapy; TNBC = triple negative breast cancer.