Table 1.
IPA Bioprofiler query displaying 70 kinases involved in HIV infection.
| Symbol | Molecule Activity | Effect on Disease or Function | Disease or Function | Causal or Correlated | Findings |
|---|---|---|---|---|---|
| ADK | increased activity | affects | HIV infection | correlation | 17 |
| MST1R | increased activity | decreases, increases |
Binding of HIV-1 | causal | 6 |
| HCK | decreased activity, increased activity |
decreases, increases |
Binding of HIV-1, Delay in replication of HIV-1, Infectivity of HIV-1, Production of HIV-1 |
causal | 5 |
| PAK1 | decreased activity, unknown change in activity |
decreases, increases |
Infection by HIV-1, Integration of HIV-1 | causal | 5 |
| AKT1 | decreased activity, increased activity |
decreases, increases |
Infection by HIV-1 | causal | 4 |
| CCNK | decreased activity, increased activity |
decreases, increases |
Replication of HIV-1 | causal | 4 |
| RAF1 | decreased activity, increased activity |
decreases, increases |
Replication of HIV-1, Transmission of HIV-1 |
causal | 4 |
| EIF2AK2 | decreased activity, increased activity |
decreases | Production of HIV-1, Replication of HIV-1 | causal | 3 |
| GRK2 | decreased activity | decreases | Infection by HIV-1 | causal | 3 |
| MAP3K11 | decreased activity, increased activity |
decreases, increases |
Infection by HIV-1 | causal | 3 |
| ZAP70 | decreased activity | decreases, increases |
Delay in replication of HIV-1, Entrance of HIV-1, Transmission of HIV-1 | causal | 3 |
| BLK | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| BMP2K | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| CHUK | increased activity | increases | Binding of HIV-1 | causal | 2 |
| COASY | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| DCAF1 | decreased activity, increased activity |
decreases, increases |
Infection by HIV-1 | causal | 2 |
| EXOSC10 | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| FYN | decreased activity | decreases | Binding of HIV-1, Production of HIV-1 | causal | 2 |
| IKBKG | decreased activity, increased activity |
Decreases, increases |
Infection by HIV-1 | causal | 2 |
| JAK1 | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| LIMK2 | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| MPP2 | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| PANK1 | decreased activity, increased activity |
decreases, increases |
Infection by HIV-1 | causal | 2 |
| PFKL | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| PFKM | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| PIKFYVE | decreased activity, increased activity | affects, decreases |
Replication of HIV | causal | 2 |
| PIP5K1C | decreased activity, increased activity | decreases, increases |
Infection by HIV-1 | causal | 2 |
| PLK1 | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| PRKAA1 | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| PRKCA | decreased activity | decreases | Binding of HIV-1, Production of HIV-1 | causal | 2 |
| PRKCH | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| WNK1 | decreased activity | decreases | Infection by HIV-1 | causal | 2 |
| BCR | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| BRDT | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| CAMK1D | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| CAMKK2 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| CCT2 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| CIB2 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| CRIM1 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| DAPK2 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| DLG1 | increased activity | affects | Replication of HIV-1 | causal | 1 |
| DMPK | increased activity | decreases | Viral release of HIV-1 | causal | 1 |
| DYRK1A | unknown change in activity | affects | Replication of HIV-1 | causal | 1 |
| EGFR | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| ERN2 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| GCK | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| ITPKA | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| LCK | increased activity | increases | Replication of HIV-1 | causal | 1 |
| LIMK1 | decreased activity | decreases | Viral entry by HIV-1 | causal | 1 |
| MAP3K14 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| MAP3K7 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| MAP3K9 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| MOS | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| MTOR | decreased activity | affects | HIV infection | correlation | 1 |
| MYLK | increased activity | affects | HIV encephalopathy | correlation | 1 |
| NEK9 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| NRBP1 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| PAK3 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| PANK3 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| PCK1 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| PI4KA | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| PKN2 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| PRKX | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| PTK2B | decreased activity | decreases | Replication of HIV-1 | causal | 1 |
| RPS6KA3 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| SIK1/SIK1B | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| SRPK3 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| TAOK1 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| TNK1 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |
| TWF1 | decreased activity | decreases | Infection by HIV-1 | causal | 1 |