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. Author manuscript; available in PMC: 2020 Apr 3.
Published in final edited form as: World J AIDS. 2019 Sep 9;9(3):142–160. doi: 10.4236/wja.2019.93011

Table 2.

Association between HIV proteins and host cell kinases.

HIV Protein Functions in Virus Lifecycle Host Cell Kinase Interactions
Nef

  • Downregulates CD4 receptor expression

  • NF-κB Activation

  • T-Cell Activation

  • Increase Tat expression

  • CCNK

  • HCK

  • PAK1
Tat

  • NF-κB dependent HIV −1 LTR activation

  • Necessary for Replication

  • RAF 1
Vif

  • Replication in Lymphocytes and Macrophages

  • Inactivation of cytidine deaminases

  • HCK